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| Name | Class |
|---|---|
| Montana State Agricultural Experiment Station | UNKNOWN |
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The purpose of this clinical trial is to determine how certain food items affect oxidative stress, inflammation, and performance recovery from exercise induced muscle damage in a resistance trained population. The main questions The investigators aim to answer are the following:
Researches will compare Haskap juice to a color, flavor and carbohydrate matched placebo to see if Haskaps speed recovery in inflammation, oxidative stress and performance.
The main goal of the clinical trial is to learn more about how the haskap berry impacts the recovery process form intense resistance training. Haskap berries are very high in several compounds that function as antioxidants, such as polyphenols and vitamin C, which have many health promoting effects. For example, antioxidants lower inflammation and oxidative stress, which is known to cause damage to cells, proteins, and DNA. Oxidative stress is a result of excess free radicals, which are unstable molecules that can be created, along with inflammation, during intense exercise. This combination of excessive harmful byproducts in the body can cause soreness and decrease muscle performance experienced after a workout. However, the antioxidants in foods have the ability to neutralize free radicals that are produced and may reduce the time to recover from exercise.
To do this, a parallel, randomized, double blind, placebo controlled clinical trial of Haskap versus a placebo on resistance trained individuals will be completed. Participants will complete an intense workout consisting of barbell back squats and leg extension. Participants will drink either Haskap juice or placebo and follow a low polyphenolic diet for a total of 11 days. Participants will have their blood drawn before supplementation, before, immediately after and 8, 24, 48, and 72 hours after the workout to track recovery of blood markers. Performance will be analyzed via vertical jumps on force plates, maximal voluntary contraction of the quadriceps on a biodex, and speed of the squat at 24, 48, and 72 hours post workout.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo Control | Placebo Comparator | The placebo supplement will have no polyphenol content and will be carbohydrate-matched to the experimental group. A twice daily dose (10-12 hours apart) will be consumed for 11 days. |
|
| Haskap | Experimental | The haskap supplement will consist of a haskap berry smoothie. A twice daily dose (10-12) hours apart will be consumed for 11 days. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Haskap berry smoothie | Dietary Supplement | A smoothie blend of berries and water |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Force Production | Maximal Voluntary Contraction (MVC) to assess force production of knee extensors at 60 degrees. | 72 hours |
| Barbell Velocity | Barbell velocity will be measure to determine how squat velocity recovers over the course of the study. | 72 hours |
| Vertical Jump | Force plates will be used to evaluate vertical jump height. | 72 hours |
| Inflammation (pg/mL) | Serum interleukin (IL) IL-6, IL-10, IL-1ra, tumor necrosis factor alpha (TNF-alpha), | 11 days |
| Lipid peroxidation | Plasma Malondialdehyde (MDA) | 11 days |
| Creatine Kinase | Plasma | 11 days |
| C-Reactive Protein | Plasma | 11 days |
| Protein Carbonyls | Plasma | 11 days |
| Measure | Description | Time Frame |
|---|---|---|
| Soreness | Soreness will be evaluated objectively by participants drawing a line on a scale of 0-10 of how sore their legs are. 0 represents no soreness at all and 10 represents the most muscular soreness the participant has felt. A lower number could indicate less inflammation and muscular damage. | 72 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Bryce Peterson | Contact | 40666975460 | brycepeterson@montana.edu | |
| Adrianna Yeats | Contact | 3864516656 | adriannayeats@montana.edu |
| Name | Affiliation | Role |
|---|---|---|
| Mary P Miles | Montana State University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Montana State University | Recruiting | Bozeman | Montana | 59715 | United States |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_ICF | Yes | No | Yes | Study Protocol and Informed Consent Form | Sep 26, 2025 | Nov 21, 2025 | Prot_ICF_000.pdf |
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| ID | Term |
|---|---|
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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Placebo and haskap interventions were designed to be comparable in taste, carbohydrate content, and appearance.
| Placebo Comparator |
| Dietary Supplement |
A smoothie with no polyphenolic content and matched in carbohydrate composition to the experimental haskap smoothie |
|
| Acute Diet |
24-hour dietary recall using the Automated Self-Administered 24-hour Dietary. Assessment Tool (ASA24). Outcome is macronutrient and micronutrient composition of food entry. |
| 9 days |
| Sleep Questionnaire | Participants report information on the previous night's sleep. What time they went to sleep, how long it took them to fall asleep, how many hours they slept, whether these were normal sleep and wake times and how restful they perceive their sleep to be on a scale of 1 to 10. 1 indicates their sleep was not restful at all and 10 indicates their sleep was as restful as possible. | 11 days |