The Intervention Effect and Potential Neural Mechanisms of Music Therapy in Children and Adolescents With Mood Disorders

The Intervention Effect and Potential Neural Mechanisms of Music Therapy in Children and Adolescents With NSSI

This study plans to combine questionnaires, scales, electrophysiological and neuroimaging methods to comprehensively evaluate the effectiveness of music therapy for children and adolescents with emotional disorders and NSSI, and explore the potential neural mechanisms of its effectiveness.

The subjects will be randomly divided into the conventional treatment group (TAU) and the music therapy group (MT). The conventional treatment group will receive DBT group therapy 5 times a week, 1 hour each time, and individual personalized therapy twice a week; the music therapy group will receive individual music therapy twice a week, 30 minutes each time, for a total of 3 weeks on top of conventional treatment.

During each intervention, near-infrared brain functional imaging, electrodermal and electrocardiographic equipment will be used to synchronously collect multimodal data from therapists and patients. The heart rate variability, electrodermal conductance response of therapists and patients, and the relative concentrations of oxygenated hemoglobin (oxy-Hb), deoxyhemoglobin (deoxy-Hb) and total hemoglobin in the brain tissue of the subjects and therapists were monitored during the treatment process.

Inclusion Criteria:

• Right-handed;
• Born and raised in China, with Chinese as the only native language;
• Voluntary participation, with the consent of the family members of patients under 18 years old, and signed the informed consent form;
• Meet the diagnostic criteria of DSM-5 anxiety disorder or depressive disorder;
• There have been two or more self-harm behaviors in the past six months.

Exclusion Criteria:

• Meet the diagnostic criteria of DSM-5 psychotic disorder, manic episode, autism spectrum disorder, mental retardation, tic disorder, substance abuse and other mental illnesses;
• Severe organic brain disease;
• Hearing loss or loss of music-related pleasure;
• Those who have clear suicidal ideation, attempt and behavior in the past month.