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| ID | Type | Description | Link |
|---|---|---|---|
| R01AG089981 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Aging (NIA) | NIH |
| Icahn School of Medicine at Mount Sinai | OTHER |
| The Methodist Hospital Research Institute | OTHER |
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This study will evaluate the validity of a digital biomarker score for precision risk stratification among older adults with aortic sclerosis or mild aortic stenosis (AS) at three US health systems.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transthoracic echocardiogram | Diagnostic Test | All study participants will undergo a clinical transthoracic echocardiogram (TTE) performed by certified echocardiography technicians. The TTE includes standard transthoracic examination with acquisition of B-mode, color and spectral Doppler images and videos in line with standard echocardiographic guidelines. |
| Measure | Description | Time Frame |
|---|---|---|
| Annualized change in AV Vmax in m/sec/years | The primary outcome measure is the annualized change in AV Vmax in m/sec/years, defined as the absolute difference between the value on the enrollment and baseline echocardiogram measurement, divided by the time difference between the studies. | From baseline TTE to TTE performed at enrollment |
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Inclusion Criteria:
Exclusion Criteria:
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US adults aged 65 and older with an echocardiogram within the prior 2-3 years that showed aortic sclerosis without stenosis or mild aortic stenosis (AS).
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| Name | Affiliation | Role |
|---|---|---|
| Rohan Khera, MD, MS | Yale University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Yale New Haven Health System | New Haven | Connecticut | 06519 | United States | ||
| Icahn School of Medicine at Mount Sinai |
A de-identified dataset will be made available following publication of primary results.
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| ID | Term |
|---|---|
| D001024 | Aortic Valve Stenosis |
| ID | Term |
|---|---|
| D000082862 | Aortic Valve Disease |
| D006349 | Heart Valve Diseases |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D004452 | Echocardiography |
| ID | Term |
|---|---|
| D057791 | Cardiac Imaging Techniques |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| New York |
| New York |
| 10029 |
| United States |
| The Methodist Hospital Research Institute | Houston | Texas | 77030 | United States |
| D014694 |
| Ventricular Outflow Obstruction |
| D014463 | Ultrasonography |
| D006334 | Heart Function Tests |
| D003935 | Diagnostic Techniques, Cardiovascular |