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The purpose of this study is to test the prognostic value of autonomic markers in patients with aortic stenosis.
Autonomic function will be assessed by presence of severe autonomic failure (defined by combination of abnormal heart rate turbulence and deceleration capacity).
Autonomic function will also be assessed by respiration and repolarization abnormalities.
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| Measure | Description | Time Frame |
|---|---|---|
| Total mortality | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Cardiovascular mortality | 2 years | |
| Combination of cardiovascular mortality and cardiac adverse events | 2 years | |
| Correlation of presence of autonomic dysfunction with severity of aortic stenosis |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with at least moderate aortic stenosis
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medizinische Klinik III | Tübingen | 72076 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22362502 | Derived | Zuern CS, Eick C, Rizas KD, Stoleriu C, Barthel P, Scherer C, Muller KA, Gawaz M, Bauer A. Severe autonomic failure in moderate to severe aortic stenosis: prevalence and association with hemodynamics and biomarkers. Clin Res Cardiol. 2012 Jul;101(7):565-72. doi: 10.1007/s00392-012-0427-3. Epub 2012 Feb 24. |
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| ID | Term |
|---|---|
| D001024 | Aortic Valve Stenosis |
| ID | Term |
|---|---|
| D000082862 | Aortic Valve Disease |
| D006349 | Heart Valve Diseases |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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It will be assessed whether patients with cardiac autonomic dysfunction have more severe aortic stenosis. Autonomic dysfunction will assumed to be present when patients suffer from "severe autonomic failure" (i.e. combination of abnormal Heart Rate Turbulence and Deceleration Capacity). Severity of aortic stenosis will be assessed by clinical (symptoms, NYHA class), hemodynamic (mean aortic gradient, aortic valve area) and biochemical (Nt-BNP, high sensitive troponins) markers. |
| at time of cardiac catheterization, which will be performed at an expected average of 3 days after hospital admission |
| D014694 |
| Ventricular Outflow Obstruction |