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The goal of this intervention study is to examine the glucose increase in blood, during 2 hours after consuming different varieties of grapes, in men and women with normal or excess body weight. The main question it aims to answer is:
can a variety of red grape reduce the glucose curve compared to a reference variety?
Participants will have to attend the Center for nutrition research facilities in three occasions, fasted for at least 8 hours. Once there, they will be measured and monitored. A canula will be inserted and once they finish eating 300g of grapes, blood extractions will be performed at minutes 15, 30, 60, 90 and 120.
The main purpose of this study is to evaluate how the glucose and insulin curves develop after consuming different grapes varieties. Still, we also want to evaluate how the serum metabolome changes with the three varieties after 120 minutes. Therefore, a metabolomic study will be done in samples of volunteers at this time point.
The intervention is longitudinal and in three arms (one per variety). Due to the harvest of the different varieties, it cannot be crossover, but each subject will consume the three varieties.
At each visit, the subjects will undergo the same schedule:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Variety 1 (timpson) | Placebo Comparator | Reference variety |
|
| Variety 2 (18INV-1438-10) | Active Comparator | First comparator |
|
| Variety 3 (18-1465-110) | Active Comparator | Second comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Grape variety control | Other | Reference grape variety |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Glycaemic response | Assessment of serum glucose evolution after consuming 50 g of carbohydrates in grapes | 0 minutes |
| Glycaemic response | Assessment of serum glucose evolution after consuming 50 g of carbohydrates in grapes | 15 minutes |
| Glycaemic response | Assessment of serum glucose evolution after consuming 50 g of carbohydrates in grapes | 30 minutes |
| Glycaemic response | Assessment of serum glucose evolution after consuming 50 g of carbohydrates in grapes | 60 minutes |
| Glycaemic response | Assessment of serum glucose evolution after consuming 50 g of carbohydrates in grapes | 90 minutes |
| Glycaemic response | Assessment of serum glucose evolution after consuming 50 g of carbohydrates in grapes | 120 minutes |
| Insulinemic response | Assessment of serum insulin evolution after consuming 50 g of carbohydrates in grapes | 0 minutes |
| Insulinemic response | Assessment of serum insulin evolution after consuming 50 g of carbohydrates in grapes |
| Measure | Description | Time Frame |
|---|---|---|
| Total cholesterol | Serum total cholesterol in fasting state | 0 minutes |
| LDL - cholesterol | Serum LDL-cholesterol in fasting state | 0 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Santiago Navas-Carretero, PhD | University of Navarra | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Center for Nutrition Research. University of Navarra | Pamplona | Navarre | 31008 | Spain |
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The group of subjects will go through the three visits of the study in the same order. All subjects will consume the same variety at the same time.
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| Grape variety 1 |
| Other |
First grape variety to evaluate |
|
| Grape variety 2 | Other | Second grape variety to evaluate |
|
| 15 minutes |
| Insulinemic response | Assessment of serum insulin evolution after consuming 50 g of carbohydrates in grapes | 30 minutes |
| Insulinemic response | Assessment of serum insulin evolution after consuming 50 g of carbohydrates in grapes | 60 minutes |
| Insulinemic response | Assessment of serum insulin evolution after consuming 50 g of carbohydrates in grapes | 90 minutes |
| Insulinemic response | Assessment of serum insulin evolution after consuming 50 g of carbohydrates in grapes | 120 minutes |
| Insulin Resistance Index (HOMA-IR) response | Assessment of insulin resistance evolution after consuming 50 g of carbohydrates in grapes | 0 minutes |
| Insulin Resistance Index (HOMA-IR) response | Assessment of insulin resistance evolution after consuming 50 g of carbohydrates in grapes | 15 minutes |
| Insulin Resistance Index (HOMA-IR) response | Assessment of insulin resistance evolution after consuming 50 g of carbohydrates in grapes | 30 minutes |
| Insulin Resistance Index (HOMA-IR) response | Assessment of insulin resistance evolution after consuming 50 g of carbohydrates in grapes | 60 minutes |
| Insulin Resistance Index (HOMA-IR) response | Assessment of insulin resistance evolution after consuming 50 g of carbohydrates in grapes | 90 minutes |
| Insulin Resistance Index (HOMA-IR) response | Assessment of insulin resistance evolution after consuming 50 g of carbohydrates in grapes | 120 minutes |
| Metabolome composition | Metabolomic analysis after grapes consumption | 120 minutes |
| HDL-cholesterol | Serum HDL-cholesterol in fasting state | 0 minutes |
| Triglycerides | Serum triglycerides in the fasting state | 0 minutes |
| ALT | Serum ALT levels in fasting state | 0 minutes |
| AST | Serum AST levels in fasting state | 0 minutes |