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| Name | Class |
|---|---|
| Biostile | INDUSTRY |
| QFarm s.r.l. | UNKNOWN |
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The randomized, open-label, two period crossover single-dose bioavailability study with two coenzyme Q10 products
The randomized, open-label, two period crossover single-dose bioavailability study with two coenzyme Q10 products will include 35 subjects who will test two different coenzyme Q10 products. Plasma concentration of coenzyme Q10 will be measured.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Coenzyme Q10 (ubiquinone) | Active Comparator | Synonyms: Maltodextrin, capsule (HPMC - hydroxypropyl methyl cellulose), coenzyme Q10 (ubiquinone); Dosage: 2 capsules, total 100 mg Co-Q10 |
|
| BMT® coenzyme Q10 | Experimental | Maltodextrin, BMT® coenzyme Q10 [maltodextrin, coenzyme Q10 (ubiquinone), stabiliser (gum arabic), corn starch, olive oil, anti-caking agent (silicon dioxide), acidity regulators (acetic acid, citric acid)], capsule (HPMC - hydroxypropyl methyl cellulose); Dosage: 2 capsules, total 100 mg Co-Q10 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dietary supplement - Active comparator | Dietary Supplement | Single dose intervention with Standard product Coenzyme Q10 (ubiquinone); 2 capsules - 100 mg total coenzyme Q10 |
|
| Measure | Description | Time Frame |
|---|---|---|
| Plasma levels of Coenzyme Q10 | Plasma levels of Coenzyme Q10 will be measured by high-performance liquid chromatography (HPLC) with electrochemical detection and a post-analytical reducing column, using a Nanospace HPLC apparatus. | At Baseline |
| Plasma levels of Coenzyme Q10 | Plasma levels of Coenzyme Q10 will be measured by high-performance liquid chromatography (HPLC) with electrochemical detection and a post-analytical reducing column, using a Nanospace HPLC apparatus. | Four hours after consumption |
| Plasma levels of Coenzyme Q10 | Plasma levels of Coenzyme Q10 will be measured by high-performance liquid chromatography (HPLC) with electrochemical detection and a post-analytical reducing column, using a Nanospace HPLC apparatus. | Six hours after consumption |
| Plasma levels of Coenzyme Q10 | Plasma levels of Coenzyme Q10 will be measured by high-performance liquid chromatography (HPLC) with electrochemical detection and a post-analytical reducing column, using a Nanospace HPLC apparatus. | Twelve hours after consumption |
| Plasma levels of Coenzyme Q10 | Plasma levels of Coenzyme Q10 will be measured by high-performance liquid chromatography (HPLC) with electrochemical detection and a post-analytical reducing column, using a Nanospace HPLC apparatus. | Twenty-four hours after consumption |
| Plasma levels of Coenzyme Q10 | Plasma levels of Coenzyme Q10 will be measured by high-performance liquid chromatography (HPLC) with electrochemical detection and a post-analytical reducing column, using a Nanospace HPLC apparatus. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Ana Petelin, phD | University of Primorska, Faculty of Health Sciences | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Primorska, Faculty of Health Sciences | Izola | Municipality of Izola | 6310 | Slovenia |
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| ID | Term |
|---|---|
| C564403 | Coenzyme Q10 Deficiency |
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| Dietary supplement - Experimental product | Dietary Supplement | Single dose intervention with Experimental product; BMT® coenzyme Q10; 2 capsules - 100 mg total coenzyme Q10 |
|
| Forthy-eight hours after consumption |