Ciprofol Based on Total Intravenous Anesthesia During Pediatric Laparoscopic Surgery

Ciprofol Based on Total Intravenous Anesthesia During Pediatric Laparoscopic Surgery: a Prospective, Double-blind, Randomized Controlled, Non Inferiority Clinical Trial

a prospective, double-blind, fully randomized controlled, non-inferiority clinical trial to investigate the use of total intravenous anesthesia in pediatric laparoscopic surgery.

Ciprofol is a better alternative to surgical sedatives. The clinical application basis of Ciprofol in pediatric anesthesia is still lacking. Therefore, the investigators designed a prospective, double-blind, fully randomized controlled, non-inferiority clinical trial to investigate the use of all-through intravenous anesthesia in pediatric laparoscopic surgery. Our main hypothesis is that in pediatric surgery, using Ciprofol by intravenous anesthesia, the extubation time is no longer than that the propofol group.

Inclusion Criteria:

• laparoscopic surgery under general anesthesia

Exclusion Criteria:

• Known allergies to propofol and ciprofol,
• Mental retardation, cognitive and affective disorders, psychiatric or neurological disorders;
• uncooperate with peripheral venipuncture and catheterization;
• History of acute upper respiratory tract infection in the past 2 weeks;
• With severe respiratory, circulation, liver and kidney insufficiency;
• Body mass index (BMI) of 30 kg/m² or 15 kg/m²;
• Known long-term use of sedative drugs;
• ASAⅢ grade or above;
• recent participation in other clinical studies.