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*Ketamine:* Ketamine is a medication that can help reduce shivering by blocking certain nerve signals in the brain. It's like a "nerve blocker" that helps calm down the body's shivering response.
- *Tramadol:* Tramadol is a pain medication that can also help reduce shivering. It works by affecting the brain's temperature regulation centers, which helps to reduce the shivering response.
Post-spinal shivering is when a patient starts shaking or shivering after receiving spinal anesthesia. This can be uncomfortable and even scary for the patient.
Using ketamine and tramadol to reduce post-spinal shivering can have several benefits, including:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group K | Active Comparator | Group K receive Inj: ketamine |
|
| Group T | Active Comparator | Group T receive Inj: Tramadol |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ketamine only | Drug | Inj: Ketamine given to group K following spinal anesthesia |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Shivering | Scale validated by crossley and mahajan Grade 0: No shivering Grade 1: Piloerection, peripheral vasoconstriction, peripheral cyanosis, or mild fasciculation of the face or neck, but no visible muscle activity Grade 2: Visible muscle activity in one muscle group Grade 3: Visible muscle activity in more than one muscle group Grade 4: Gross muscle activity involving the entire body | 20 minutes to 12 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Nazish Dr Nazish Kanwal | Contact | 03292163092 | Naz98783@gmail.com | |
| Shazor khan Khattak | Contact | +92 340 2286119 | shazorkhan646@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Nazish Dr Nazish Kanwal | Liaquat national hospital and medical college | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Liaquat National Hospital and Medical College | Recruiting | Karachi | Sindh | 75500 | Pakistan |
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| Label | URL |
|---|---|
| The effect of ketamine versus tramadol on prophylactic post-spinal shivering in those patients undergoing orthopedic surgery: a prospective cohort study design, 2020 Ashebir Debalike Gemechu 1, Tsegaye Demeke Gebremedhin 1,✉, Andualem Assefa Andebiku 1, | View source |
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Patient confidentiality*: Sharing IPD could compromise patient confidentiality and anonymity, potentially harming participants or their families.
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| ID | Term |
|---|---|
| D014147 | Tramadol |
| ID | Term |
|---|---|
| D003511 | Cyclohexanols |
| D000441 | Hexanols |
| D005233 | Fatty Alcohols |
| D000438 | Alcohols |
| D009930 |
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| Tramadol |
| Drug |
Inj Tramadol given to group T following spinal anesthesia |
|
| Liaquat National Hospital and Medical College | Recruiting | Karachi | Sindh | Pakistan |
|
| Liaquat National Hospital and Medical College | Recruiting | Karachi | Sindh | Pakistan |
|
| Organic Chemicals |
| D004123 | Dimethylamines |
| D008744 | Methylamines |
| D000588 | Amines |
| D008055 | Lipids |