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| Name | Class |
|---|---|
| Prof FONG NAI KUEN KENNETH | UNKNOWN |
| Dr LI SHI PUI | UNKNOWN |
| Dr NG HIU FUNG PETER | UNKNOWN |
| Johns Hopkins University |
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The goal of this RCT is to investigate if computerized script training may promote functional communication and nonverbal cognitive functions of Cantonese-speaking PWA, and whether VR may further magnify the treatment outcomes.
The main research questions are:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| VR-based script training | Experimental |
| |
| Control | No Intervention | ||
| Computerized script training without VR | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| VR-based script training | Behavioral | The PWA will wear a head-mounted VR device (e.g., Metaverse Oculus Quest 2 or other commercially available devices) for 30 minutes, which intends to create an immersive environment for training. Scripts trained in the computerized script training program in a particular session will be practiced. Cinematic 360Ëš photo-real scenarios of daily contexts such as a restaurant or a grocery store will be displayed in the device while a communication partner, e.g., a waiter in the restaurant or a shopkeeper of a grocery store will initiate the conversation by producing the corresponding part of the script. The PWA will be given time to respond. Upon the completion of PWA's respond, the next conversational turn will be initiated. The clinical assistant, who accompanies the PWA in the entire training session, will control the flow of the 360 Ëš videos. |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage accuracy of treatment probe correctly produced | Participant's production accuracy of the trained scripts in read-aloud and no-cue conditions. | From baseline up to 8-week post training |
| Time to produce each of the scripts in the treatment probe | Participant's production time of the trained scripts in read-aloud and no-cue conditions. | From baseline up to 8-week post training |
| Number of sessions to reach performance criteria in session probe | From baseline up to 8-week post training |
| Measure | Description | Time Frame |
|---|---|---|
| Cantonese version of the Western Aphasia Battery (CAB) to measure aphasia severity | From baseline up to 8-week post training | |
| Cantonese version of the Amsterdam-Nijmegen Everyday Language Test to measure verbal communication effectiveness in conversation via 20 culturally appropriate scenarios |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Winsy WS Wong, PhD | Contact | 852-34003117 | wszewong@polyu.edu.hk |
| Name | Affiliation | Role |
|---|---|---|
| Winsy WS Wong, PhD | The Hong Kong Polytechnic University | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42228712 | Derived | Wong WWS, Li DSP, Fong KNK, Ng PHF, Kwok HTK. Can immersive virtual reality magnify treatment outcomes of computerized script training on Cantonese speakers with chronic aphasia? Protocol of a randomized controlled trial. PLoS One. 2026 Jun 2;21(6):e0350390. doi: 10.1371/journal.pone.0350390. eCollection 2026. |
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The IPD, together with the study protocol, will be shared in an open-access data repository (e.g., OSF).
Data will be shared starting from three months after manuscript publication.
The IPD and study protocol will be shared in an open-access data repository without restrictions.
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| ID | Term |
|---|---|
| D001037 | Aphasia |
| ID | Term |
|---|---|
| D013064 | Speech Disorders |
| D007806 | Language Disorders |
| D003147 | Communication Disorders |
| D019954 | Neurobehavioral Manifestations |
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| OTHER |
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| Conventional script training | Behavioral | The flow of training is identical to the VR condition, except that photos depicting the scenarios and prerecorded conversational turns will be presented to the PWA on a computer screen with the same procedures mentioned in the VR condition. |
|
| From baseline up to 8-week post training |
| Cantonese version of the 20-item Communication Outcome after Stroke (Can-COAST) as a self-reported outcome on communication and quality of life | The questionnaire consists of 20 questions, and participants will be asked to evaluate their functional communication and quality of life based on a 5-point Likert scale. Higher scores reflect better functional communication performance and quality of life. | From baseline up to 8-week post training |
| Subtest 1 (map search) and 3 (elevator counting) of Test of Everyday Attention to assess attention | The sub-test 1 aims to tap sustained and selective visual attention via identifying the target symbol in a map while the sub-test 3 assesses auditory selective attention via counting the number of target tones in the presence of distractors with different tones. | From baseline up to 8-week post training |
| Digit span forward and backward task to assess verbal short-term and working memory | The longest span of participant correctly recalled in the digit span forward and backward task. | From baseline up to 8-week post training |
| Test of Nonverbal Intelligence-third edition (TONI-3) to assess executive function | A norm-referenced test that uses abstract figures to evaluate abstract reasoning and problem-solving. | From baseline up to 8-week post training |
| Wisconsin Card Sort Test (WCST) to assess executive function | WCST assesses cognitive flexibility and reasoning via matching cards with respect to color, quantity, and shape upon different rules and feedback given. | From baseline up to 8-week post training |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |