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The goal of this intervention study is to investigate the effects of immersive virtual reality in rehabilitation of language and communication of individuals with post-stroke aphasia. The main research questions are:
Participants will be assessed before, in the middle of, immediately after treatment and 8-week post treatment in terms of their performance on:
The participants will be randomly allocated to receive one of the treatment:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| VR-based script training | Experimental |
| |
| Conventional script training | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| VR-based script training | Behavioral | The PWA will wear a head-mounted VR device (e.g., Metaverse Oculus Quest 2 or other commercially available devices) for 30 minutes, which intends to create an immersive environment for training. Scripts trained in the computerized script training program in a particular session will be practiced. Cinematic 360Ëš photo-real scenarios of daily contexts such as a restaurant or a grocery store will be displayed in the device while a communication partner, e.g., a waiter in the restaurant or a shopkeeper of a grocery store will initiate the conversation by producing the corresponding part of the script. The PWA will be given time to respond. Upon the completion of PWA's respond, the next conversational turn will be initiated. The clinical assistant, who accompanies the PWA in the entire training session, will control the flow of the 360 Ëš videos. |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage correct in reading aloud the sentences included in the trained scripts | Trained scripts will be shown in written form while the PWA will be asked to read aloud the scripts. | From baseline up to 1-week post training |
| Time required in read aloud of trained scripts | Total time to read aloud the trained scripts | From baseline up to 1-week post training |
| Percentage correct in spontaneous production of the sentences included in the trained scripts | No written cue will be provided while the PWA will produce the scripts upon questions. | From baseline up to 1-week post training |
| Time required for spantaneous production of trained scripts | No written cue will be provided while the PWA will produce the scripts upon questions. | From baseline up to 1-week post training |
| Measure | Description | Time Frame |
|---|---|---|
| CAB | Cantonese version of the Western Aphasia Battery | From baseline up to 1-week post training |
| CANELT | Cantonese version of the Amsterdam-Nijmegen Everyday Language Test (ANELT; Blomert et al., 1994) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Winsy WS Wong, PhD | The Hong Kong Polytechnic University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hong Kong Polytechnic University | Hong Kong | Hong Kong SAR | 852 | Hong Kong |
The IPD, together with the study protocol, will be shared in an open-access data repository (e.g., Harvard Dataverse).
Data will be shared starting from three months after manuscript publication.
The IPD and study protocol will be shared in an open-access data repository without restrictions.
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| ID | Term |
|---|---|
| D001037 | Aphasia |
| ID | Term |
|---|---|
| D013064 | Speech Disorders |
| D007806 | Language Disorders |
| D003147 | Communication Disorders |
| D019954 | Neurobehavioral Manifestations |
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|
| Conventional script training | Behavioral | The flow of training is identical to the VR condition, except that photos depicting the scenarios and pre-recorded conversational turns will be presented to the PWA on a computer screen with the same procedures mentioned in the VR condition. |
|
| From baseline up to 1-week post training |
| Percentage correct in producing untrained but related scripts | No written cue will be provided while the PWA will produce the untrained scripts that share similar contexts with the trained scripts. | From baseline up to 1-week post training |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |