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| Name | Class |
|---|---|
| Centre for Infectious Disease Research in Zambia | OTHER |
| National Academy of Medical Sciences, Nepal | OTHER_GOV |
| University of Oxford | OTHER |
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The overall objective of the PREVENT trial is to evaluate the effectiveness of an integrated, school-based program for the prevention of rheumatic heart disease (RHD) in regions with an endemic pattern of RHD.
We conduct a stepped wedge cluster randomized trial in randomly selected schools in Nepal and Zambia.
The intervention will be delivered at the level of the school and consists in the introduction of a dedicated school-nurse program providing health care through education about RHD, assessment, intervention, and follow-up of GABHS pharyngitis, and facilitation of secondary antibiotic prophylaxis for children with RHD.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| School nurse program | Experimental | The experimental intervention consists in a school nurse program providing integrated health care through diagnosis, intervention, and follow-up of group A beta-hemolytic streptococcal pharyngitis, and facilitation of secondary antibiotic prophylaxis for children with rheumatic heart disease. |
|
| Standard of care | No Intervention | No school nurse prorgam. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| School nurse program | Other | The intervention consists in the introduction of a school-nurse program providing health care through education about rheumatic heart disease, assessment, intervention, and follow-up of group A beta-hemolytic streptococcal pharyngitis, and facilitation of secondary antibiotic prophylaxis for children with rheumatic heart disease. |
| Measure | Description | Time Frame |
|---|---|---|
| Rheumatic heart disease | The primary outcome of the study will be the reduction in prevalence of rheumatic heart disease according to WHF criteria 2023 as assessed by systematic echocardiographic screening. | The endpoint will be assessed after a minimum of 1 and a maximum of 3 years after introduction of the school nurse program. |
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Inclusion Criteria:
- Children aged 5-16 years
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Thomas Pilgrim Bern University Hospital, Bern, Switzerland | Contact | +41 31 632 08 27 | thomas.pilgrim@insel.ch |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Academy od Medical Sciences | Recruiting | Kathmandu | Nepal |
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| ID | Term |
|---|---|
| D012214 | Rheumatic Heart Disease |
| D006349 | Heart Valve Diseases |
| D012213 | Rheumatic Fever |
| ID | Term |
|---|---|
| D013290 | Streptococcal Infections |
| D016908 | Gram-Positive Bacterial Infections |
| D001424 | Bacterial Infections |
| D001423 | Bacterial Infections and Mycoses |
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Stepped wedge cluster randomized trial
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| Centre of Infectious Disease Research | Recruiting | Lusaka | Zambia |
|
| D007239 | Infections |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
| D003240 | Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |