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This study explores whether rapid non-invasive brain stimulation can help reduce hoarding disorder symptoms.
Hoarding disorder (HD) is characterized by difficulty letting go of possessions, leading to clutter that congests living spaces and impairs daily functioning. The majority of HD patients treated with cognitive behavioral therapy for HD usually experience considerable residual symptoms. New treatments are greatly needed. This study explores whether rapid non-invasive brain stimulation can help reduce hoarding disorder symptoms.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Theta-burst stimulation (TBS) | Experimental | Theta-burst stimulation (a form of transcranial magnetic stimulation) targeting the right frontal pole. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MagPro X100 by MagVenture | Device | Participants will receive 5 session per day of TBS for 6 days (30 sessions total). Six treatment days have to occur within a 2 week period. Each session will be comprised of 1800 pulses, using a MagVenture MagPro X100. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Compulsive Acquisition Scale (CAS) | The Compulsive Acquisition Scale (CAS) is an 18-item questionnaire that measures the extent to which individuals acquire and feel compelled to acquire possessions. The total score (sum of 18 items) ranges from 0 to 126. Total score higher than 48 shows significant difficulty with acquiring. | Change from baseline to 3 weeks after treatment starts |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in Hoarding Symptom Severity as Measured by Saving Inventory-Revised (SI-R) | The Saving Inventory-Revised scale (SI-R) is a 23-item questionnaire with 3 factor-analytically defined sub-scales for difficulty discarding, excessive clutter, and compulsive acquisition. The total score (sum of 23 items) ranges from 0 to 92. Total score higher than 41 shows significant difficulty with clutter. For the acquisition subscale, items 2 (reverse score), 9, 11, 14, 16, 18 and 21 are summed together. The subscale ranges from 0 to 28 and score greater than 13 indicates difficulty with excessive acquisition. For the difficulty discarding subscale, items 4(reverse score), 6, 7, 13, 17, 19, 23 are summed together. The subscale ranges from 0 to 28 and score greater than 13 indicates difficulty with discarding. For the clutter subscale, items 1, 3, 5, 8, 10, 12, 15, 20, 22 are summed together. The subscale ranges from 0 to 36 and score greater than 15 indicates difficulty with accumulated clutter. |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Paula Munoz Rodriguez, PhD | Contact | 650-723-4095 | clutterhelp@stanford.edu |
| Name | Affiliation | Role |
|---|---|---|
| Carolyn I Rodriguez, MD, PhD | Stanford University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Stanford University Medical Center | Recruiting | Palo Alto | California | 94305 | United States |
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| Label | URL |
|---|---|
| Rodriguez Lab Website | View source |
| Dr. Carolyn Rodriguez (PI) Stanford Faculty Profile | View source |
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| ID | Term |
|---|---|
| D000067836 | Hoarding Disorder |
| D060845 | Hoarding |
| D013064 | Speech Disorders |
| ID | Term |
|---|---|
| D009771 | Obsessive-Compulsive Disorder |
| D001008 | Anxiety Disorders |
| D001523 | Mental Disorders |
| D001519 | Behavior |
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| Change from baseline to 3 weeks after treatment starts |
| D007806 |
| Language Disorders |
| D003147 | Communication Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |