Transcranial Magnetic Stimulation Treatment of Hoarding Disorder

Transcranial Magnetic Stimulation Treatment of Hoarding Disorder

This is multiple baseline study including up to three participants with a primary diagnosis of hoarding disorder. All patients will receive unblinded repetitive transcranial magnetic stimulation study intervention.

Study assessments will be conducted at pre-baseline, weekly during baseline assessment (until a stable baseline is established, but not less than 2, 4, and 6 weeks for patients respectively), weekly during treatment, and at post-treatment. Magnetic resonance imaging (MRI) will be competed at pre-baseline, pre-treatment, and post-treatment. Treatment will entail daily (5 days/week) sessions of repetitive transcranial magnetic stimulation using the Neurostar Therapy System for 6 weeks employing right-sided, low frequency stimulation (1 Hz, 900 pulses/session for 30 sessions, 27,000 total pulses, intensity at 90% of the passive motor threshold) to the dorsolateral prefrontal cortex (DLPFC). Neuronavigation will direct coil placement over the DLPFC based upon structural MRI.

Inclusion Criteria:

• Diagnosed with hoarding disorder as primary disorder
• Clinical Global Impression Score > 3
• Saving Inventory-Revised score > 39

Exclusion Criteria:

• Any contraindication for participation in magnetic resonance imaging or transcranial magnetic stimulation
• Severe and/or unstable medical or psychiatric condition that require immediate medical attention
• Diagnosed with current major depressive episode
• Currently taking psychiatric medication