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| ID | Type | Description | Link |
|---|---|---|---|
| 5R37CA259156-04 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Cancer Institute (NCI) | NIH |
| AmeriSpeak - NORC | UNKNOWN |
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NORC/AmeriSpeak will recruit participants who meet the study criteria and invite them to complete a 15-minute survey. Participants will be randomly assigned to one of five conditions, with approximately 400 people in each condition, and will respond to various questions after viewing the study messaging. Once 2,000 participants complete the survey, the data will be de-identified and provided to the study team for analysis.
NORC/AmeriSpeak will put all of the study content into their system. They will send out the opportunity to participate in the study, which should take about 15 minutes, to people in their panel who meet our participation criteria. Participants will be directed to the study information sheet that includes all elements of consent. Participants who agree to participate will start the survey experiment. The survey experiment will randomize participants into one of five conditions: (1) control (no exposure), (2) overall median ranked messages (from the prior study), (3) messages preferred by all participants, (4) messages preferred by Black American participants, and (5) messages preferred by White American participants. Approximately 400 people will complete each condition. After viewing the study stimuli (or no stimuli in the control condition), participants will respond to various outcomes and other variables of interest (see questionnaire draft included). After all 2,000 people have completed the study, the study team will receive a de-identified data file from NORC/AmeriSpeak with all study data and engage in analysis. This study is planned to close the study around that time as the study team completes data analysis and write-up the findings.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control (no exposure) | Placebo Comparator | Participants in the Control Arm will not be shown any messages. |
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| Median Ranked | Experimental | Participants in the Median Ranked Arm will be shown four Median Ranked messages. |
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| Overall Preferred | Experimental | Participants in the Overall Preferred arm will be shown four Overall Preferred messages. |
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| Black American Preferred | Experimental | Participants in the Black American Preferred arm will be shown four Black American Preferred messages. |
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| White American Preferred | Experimental | Participants in the White American Preferred arm will be shown four White American Preferred messages. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Median Ranked Cancer Screening Messaging | Behavioral | Strong message content that increases screening and sharing intentions. Messages in this intervention were median ranked in the prior study. |
| Measure | Description | Time Frame |
|---|---|---|
| Intentions to Adhere to Colorectal Cancer Screening (CRCS) Recommendations | After reading cancer screening (CRCS) recommendations, this outcome will assess how likely they are to follow on the the screening recommendations. Response options: Very unlikely (1), unlikely, neither unlikely nor likely, likely, very likely (5) A higher score indicates a favorable outcome, and a lower score indicates a less favorable outcome. | 15 minutes |
| Intentions to Adhere Test Preference Indication | To determine which colorectal cancer screening (CRCS) participants are most likely to choose. Response options: stool-based tests (e.g., FOBT or FIT); endoscopic/scoping approach (e.g., colonoscopy or sigmoidoscopy); whatever my doctor recommends to me; something other than a stool-based or scoping approach; I would not follow the recommendations. This outcome will report the count of responses. | 15 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Likelihood of Sharing Information Via Social Media | This outcome measure will determine how likely participants are to share the messages about colon cancer screening on social media. Response options: Very unlikely (1), unlikely, neither unlikely nor likely, likely, very likely (5) A higher score indicates a favorable outcome, and a lower score indicates a less favorable outcome. | 15 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Andy King, PhD | Huntsman Cancer Institute/ University of Utah | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Andy King | Salt Lake City | Utah | 84112 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41620698 | Derived | King AJ, Liao Y, Chen T, Kanrar R, Chunara R, Margolin D, Nettleton D, Niederdeppe J. Testing the effects of segmented crowdsource-selected messages to improve intentions to follow colorectal cancer screening recommendations: study protocol for a randomized controlled trial. BMC Public Health. 2026 Jan 31;26(1):755. doi: 10.1186/s12889-026-26440-2. |
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De-identified data will be shared/uploaded to an online data repository like OSF.
Once the primary results are published in a peer-reviewed journal article, the de-identified data will be published in an online data repository. The data will then be available for as long as the online repository is available
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| ID | Title | Description |
|---|---|---|
| FG000 | Control (no Exposure) | Participants in the Control Arm will not be shown any messages. Control: There will be no message content of cancer screening and sharing intentions in this arm. |
| FG001 | Median Ranked | Participants in the Median Ranked Arm will be shown four Median Ranked messages. Median Ranked Cancer Screening Messaging: Strong message content that increases screening and sharing intentions. Messages in this intervention were median ranked in the prior study. |
| FG002 | Overall Preferred | Participants in the Overall Preferred arm will be shown four Overall Preferred messages. Overall Preferred Cancer Screening Messaging: Strong message content that increases screening and sharing intentions. Messages in this intervention were highly rated messages by all participants in the prior study. |
| FG003 | Black American Preferred | Participants in the Black American Preferred arm will be shown four Black American Preferred messages. Black American Preferred Cancer Screening Messaging: Strong message content that increases screening and sharing intentions. Messages in this intervention were highly rated messages by Black participants but not White participants in the prior study. |
| FG004 | White American Preferred | Participants in the White American Preferred arm will be shown four White American Preferred messages. White American Preferred Cancer Screening Messaging: Strong message content that increases screening and sharing intentions. Messages in this intervention were highly rated messages by White participants but not Black participants. |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
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| ID | Title | Description |
|---|---|---|
| BG000 | Overall Preferred | Participants in the Overall Preferred arm will be shown four Overall Preferred messages. Overall Preferred Cancer Screening Messaging: Strong message content that increases screening and sharing intentions. Messages in this intervention were highly rated messages by all participants in the prior study. |
| BG001 |
| Units | Counts |
|---|---|
| Participants |
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| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Categorical | Count of Participants |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Intentions to Adhere to Colorectal Cancer Screening (CRCS) Recommendations | After reading cancer screening (CRCS) recommendations, this outcome will assess how likely they are to follow on the the screening recommendations. Response options: Very unlikely (1), unlikely, neither unlikely nor likely, likely, very likely (5) A higher score indicates a favorable outcome, and a lower score indicates a less favorable outcome. | One participant in the Black American Preferred group left this item blank. | Posted | Count of Participants | Participants | 15 minutes |
|
Adverse event data was not collected for this study.
All-Cause Mortality data was not collected for this study..
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Overall Preferred | Participants in the Overall Preferred arm will be shown four Overall Preferred messages. Overall Preferred Cancer Screening Messaging: Strong message content that increases screening and sharing intentions. Messages in this intervention were highly rated messages by all participants in the prior study. |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Andy King | University of Utah | 801-646-4274 | andy.king@utah.edu |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Sep 16, 2025 | Jan 16, 2026 | Prot_SAP_000.pdf |
| ICF | No | No | Yes | Informed Consent Form | Nov 13, 2024 | Jan 16, 2026 | ICF_001.pdf |
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| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| ID | Term |
|---|---|
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
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| Overall Preferred Cancer Screening Messaging | Behavioral | Strong message content that increases screening and sharing intentions. Messages in this intervention were highly rated messages by all participants in the prior study. |
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| Black American Preferred Cancer Screening Messaging | Behavioral | Strong message content that increases screening and sharing intentions. Messages in this intervention were highly rated messages by Black participants but not White participants in the prior study. |
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| White American Preferred Cancer Screening Messaging | Behavioral | Strong message content that increases screening and sharing intentions. Messages in this intervention were highly rated messages by White participants but not Black participants. |
|
| Control | Behavioral | There will be no message content of cancer screening and sharing intentions in this arm. |
|
| Information Sharing Behavior | This outcome will report the count of participants will seek more information after the study. The participants will be asked a question on if they would like more information (Yes/No) and survey vendor will track participants who click a link to an external resource like the American Cancer Society to learn more. | 15 minutes |
| Black American Preferred |
Participants in the Black American Preferred arm will be shown four Black American Preferred messages. Black American Preferred Cancer Screening Messaging: Strong message content that increases screening and sharing intentions. Messages in this intervention were highly rated messages by Black participants but not White participants in the prior study. |
| BG002 | White American Preferred | Participants in the White American Preferred arm will be shown four White American Preferred messages. White American Preferred Cancer Screening Messaging: Strong message content that increases screening and sharing intentions. Messages in this intervention were highly rated messages by White participants but not Black participants. |
| BG003 | Median Ranked | Participants in the Median Ranked Arm will be shown four Median Ranked messages. Median Ranked Cancer Screening Messaging: Strong message content that increases screening and sharing intentions. Messages in this intervention were median ranked in the prior study. |
| BG004 | Control (no Exposure) | Participants in the Control Arm will not be shown any messages. Control: There will be no message content of cancer screening and sharing intentions in this arm. |
| BG005 | Total | Total of all reporting groups |
| Participants |
|
| Age, Continuous | Mean | Standard Deviation | years |
|
| Sex: Female, Male | Count of Participants | Participants |
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| Ethnicity (NIH/OMB) | Count of Participants | Participants |
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| Race (NIH/OMB) | Count of Participants | Participants |
|
| Region of Enrollment | Number | participants |
|
| OG001 | Black American Preferred | Participants in the Black American Preferred arm will be shown four Black American Preferred messages. Black American Preferred Cancer Screening Messaging: Strong message content that increases screening and sharing intentions. Messages in this intervention were highly rated messages by Black participants but not White participants in the prior study. |
| OG002 | White American Preferred | Participants in the White American Preferred arm will be shown four White American Preferred messages. White American Preferred Cancer Screening Messaging: Strong message content that increases screening and sharing intentions. Messages in this intervention were highly rated messages by White participants but not Black participants. |
| OG003 | Median Ranked | Participants in the Median Ranked Arm will be shown four Median Ranked messages. Median Ranked Cancer Screening Messaging: Strong message content that increases screening and sharing intentions. Messages in this intervention were median ranked in the prior study. |
| OG004 | Control (no Exposure) | Participants in the Control Arm will not be shown any messages. Control: There will be no message content of cancer screening and sharing intentions in this arm. |
|
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| Primary | Intentions to Adhere Test Preference Indication | To determine which colorectal cancer screening (CRCS) participants are most likely to choose. Response options: stool-based tests (e.g., FOBT or FIT); endoscopic/scoping approach (e.g., colonoscopy or sigmoidoscopy); whatever my doctor recommends to me; something other than a stool-based or scoping approach; I would not follow the recommendations. This outcome will report the count of responses. | Posted | Count of Participants | Participants | 15 minutes |
|
|
|
| Secondary | Likelihood of Sharing Information Via Social Media | This outcome measure will determine how likely participants are to share the messages about colon cancer screening on social media. Response options: Very unlikely (1), unlikely, neither unlikely nor likely, likely, very likely (5) A higher score indicates a favorable outcome, and a lower score indicates a less favorable outcome. | Posted | Count of Participants | Participants | 15 minutes |
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|
|
| Secondary | Information Sharing Behavior | This outcome will report the count of participants will seek more information after the study. The participants will be asked a question on if they would like more information (Yes/No) and survey vendor will track participants who click a link to an external resource like the American Cancer Society to learn more. | One participant in the Control group did not complete this item. | Posted | Count of Participants | Participants | 15 minutes |
|
|
|
| 0 |
| 0 |
| 0 |
| 0 |
| 0 |
| 0 |
| EG001 | Black American Preferred | Participants in the Black American Preferred arm will be shown four Black American Preferred messages. Black American Preferred Cancer Screening Messaging: Strong message content that increases screening and sharing intentions. Messages in this intervention were highly rated messages by Black participants but not White participants in the prior study. | 0 | 0 | 0 | 0 | 0 | 0 |
| EG002 | White American Preferred | Participants in the White American Preferred arm will be shown four White American Preferred messages. White American Preferred Cancer Screening Messaging: Strong message content that increases screening and sharing intentions. Messages in this intervention were highly rated messages by White participants but not Black participants. | 0 | 0 | 0 | 0 | 0 | 0 |
| EG003 | Median Ranked | Participants in the Median Ranked Arm will be shown four Median Ranked messages. Median Ranked Cancer Screening Messaging: Strong message content that increases screening and sharing intentions. Messages in this intervention were median ranked in the prior study. | 0 | 0 | 0 | 0 | 0 | 0 |
| EG004 | Control (no Exposure) | Participants in the Control Arm will not be shown any messages. Control: There will be no message content of cancer screening and sharing intentions in this arm. | 0 | 0 | 0 | 0 | 0 | 0 |
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| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |
| Endoscopic/Scoping |
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| Doctor's recommendation |
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| Something other than stool-based/scoping |
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| Would not follow recommendation |
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| 2 Unlikely |
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| 3 Neutral |
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| 4 Likely |
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| 5 Very Likely |
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| No |
|