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| ID | Type | Description | Link |
|---|---|---|---|
| R21MD016506 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institutes of Health (NIH) | NIH |
| National Institute on Minority Health and Health Disparities (NIMHD) | NIH |
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Colorectal cancer (CRC) is one of the leading causes of cancer mortality in the United States, and African Americans (AfAms) still fare worse in CRC incidence and mortality compared to European Americans (EuAms). We propose to examine whether combining both fear-reduction and racially-targeted norm-based messages will increase at-home stool-based CRC screening receptivity and uptake for all African American regardless of level of racial identity. Given low return rates of at-home screening kits, we will also explore whether making an explicit commitment to return screening kits is associated with increased kit returns.
Colorectal cancer (CRC) is one of the leading causes of cancer mortality in the United States, and African Americans (AfAms) still fare worse in CRC incidence and mortality compared to European Americans (EuAms).Interventions to increase CRC screening rates among AfAms are instrumental to address the disparities in CRC incidence and mortality. Despite literature indicating that AfAms' fears (e.g., of colonoscopy procedures or cancer diagnosis) serve as barriers to CRC screening, no interventions have used theory-guided methods to directly target fear-based beliefs. Additionally, no research has examined the extent to which racial identity moderates the effects of racially targeted messaging, despite the ubiquity of using targeted health messaging entreaties among minority groups. This is particularly relevant given our work showing that racially-targeted screening entreaties increased CRC screening intentions among AfAms who identified less strongly, but depressed those intentions among AfAms who identified more strongly with their racial group. Lack of focus on other salient CRC screening barriers may have been off-putting to highly identified African Americans. We propose to examine whether combining both fear-reduction and racially-targeted norm-based messages will increase at-home stool-based CRC screening receptivity and uptake for all African American regardless of level of racial identity. Given low return rates of at-home screening kits, we will also explore whether making an explicit commitment to return screening kits is associated with increased kit returns.
Aim 1: To develop and refine a fear-reduction intervention guided by the theory of planned behavior and by published literature, in conjunction with AfAm community experts.
Aim 2: To examine whether the fear-reduction entreaty increases receptivity to, and uptake of at-home CRC screening when coupled with racially-targeted norm-based messages.
Aim 3: To examine the moderating roles of racial identity and perceived CRC risk on the effects of fear-reduction and racially-targeted norm-based messaging entreaties.
Aim 4: We will explore whether participants who make explicit commitments to return FIT Kits return them at a higher rate compared to those who do not make such commitments.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Norm Based Messages | Experimental | One of 3 messaging entreaties based on normative perceptions of colorectal cancer screening, and one no norm-based messaging arm. |
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| Fear Reduction Message | Experimental | Participants randomized to receive (or not receive) messaging entreaty to address colorectal cancer screening fears. |
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| Commitment | Experimental | Participants randomized to indicate explicit commitment to return FIT Kits for processing. |
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| Control | No Intervention | Participants receive no health messages. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Racial group-targeted messages | Other | Colorectal cancer screening messages targeted towards participants racial group. |
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| Measure | Description | Time Frame |
|---|---|---|
| FIT Kit request | FIT Kit request | Immediately after survey |
| Measure | Description | Time Frame |
|---|---|---|
| FIT Kit return | Mailing completed FIT Kit to lab for processing | 3 months |
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Inclusion Criteria:
African American Overdue to colorectal cancer screening Has primary care physician Not at high risk for colorectal cancer
Exclusion Criteria:
Not meeting inclusion criteria
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| Name | Affiliation | Role |
|---|---|---|
| Mark Manning, PhD | Oakland University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Oakland University | Rochester | Michigan | 48309 | United States |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Nov 20, 2025 | |
| Reset | Dec 15, 2025 | |
| Release | Jan 2, 2026 | |
| Reset | Jan 20, 2026 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Nov 20, 2025 | Dec 15, 2025 | |||
| Jan 2, 2026 |
| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| ID | Term |
|---|---|
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
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| Explicit Commitment | Other | Indicate explicit commitment to return at home screening kit. |
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| Jan 20, 2026 |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |