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Liver transplantation (LT) has become an accepted treatment for selected patients with unresectable liver metastases due to colorectal cancer (CRLM). The goal of this study is to look at and compare the clinical results of all the different approved methods (living vs. Deceased, whole organ vs. Split, one staged vs. Two staged) used to perform a standard liver transplant procedure for recipients with CRLM. Investigators will look at things like different procedure results, recovery in the hospital, and survival rates one year after the transplant. Investigators will also take blood samples from participants to be used in future research. All the transplant methods the investigators are comparing are standard practices approved by the United Network of Organ Sharing (UNOS).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Living Donor Liver Transplant | Living Donor Liver Transplant using right or left lobe donor graft | ||
| RAPID Living Donor Liver Transplant (using LLS or left lobe) | Resection And Partial Liver Transplantation with Delayed Total Hepatectomy is a two staged procedure that utilized partial donor grafts and stages hepatectomies. In the first stage, a left hepatectomy is performed and a LT is performed using a donor left lateral segment split (LLS) (or left lobe split in some circumstances). Once the LT has achieved sufficient volume (typically within two weeks), a right hepatectomy is performed to remove all native liver, leaving the LT intact. | ||
| RAPID Deceased Donor Liver Transplant (LLS or left lobe) | Resection And Partial Liver Transplantation with Delayed Total Hepatectomy is a two staged procedure that utilized partial donor grafts and stages hepatectomies. In the first stage, a left hepatectomy is performed and a LT is performed using a donor left lateral segment split (LLS) (or left lobe split in some circumstances). Once the LT has achieved sufficient volume (typically within two weeks), a right hepatectomy is performed to remove all native liver, leaving the LT intact. | ||
| Liver Transplant Deceased Donor (Whole Liver) | The whole of the deceased donor liver is used. Livers from deceased donors are allocated to potential recipients according to the MELD (Model for End-Stage Liver Disease) scoring system. |
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| Measure | Description | Time Frame |
|---|---|---|
| Graft and Patient Survival Outcomes | Graft survival will be measured as the time from transplantation to graft failure, or re-transplantation date. | From liver transplant to 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Outcomes of liver transplant recipients | Evaluate outcomes (e.g., complications or surgical outcomes) of liver transplant (LT) recipients. | From liver transplant to 12 months |
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Inclusion:
Exclusion:
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Northwestern University participants with liver metastases due to colorectal cancer (CRLM) who are eligible to liver transplant candidates
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yajaira Navarro | Contact | 312-694-2092 | a-daud@northwestern.edu |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Northwestern University-Comprehensive Transplant Center | Recruiting | Chicago | Illinois | 60611 | United States |
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| ID | Term |
|---|---|
| D015179 | Colorectal Neoplasms |
| ID | Term |
|---|---|
| D007414 | Intestinal Neoplasms |
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
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| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D003108 | Colonic Diseases |
| D007410 | Intestinal Diseases |
| D012002 | Rectal Diseases |