Effect of Two Different Doses of Neostigmine on the Gastric Residual Volume and Aspiration in Critically Ill Patients

Effect of Two Different Doses of Neostigmine on the Gastric Residual Volume and Aspiration in Critically Ill Patients Under Enteral Feeding; a Comparative Controlled Randomized Trial

A study comparing the effect of two doses of neostigmine on the gastric residual volume in critically ill patients on enteral feeding.

Participants were categorized into three groups: Group I and Group II received neostigmine 1 mg and 2 mg, respectively, and a control group received 10 ml of normal saline. All participants received an intravenous administration of 10 mg of metoclopramide. GRV was measured every 3 hours before enteral feeding. aspiration through nasogastric (NG) or orogastric (OG) tubes was done before the next due bolus of feeding.

Inclusion Criteria:

• patients with a GRV >120ml
• a normal heart rateExclusion Criteria
• absence of comorbidities such as diabetes and renal failure. exclusion Criteria:
• Patients exhibiting new-onset arrhythmias or heart block
• hypotension (systolic blood pressure less than 60 mmHg)
• experiencing active gastrointestinal bleeding or receiving prokinetic medications 8-12 hours before the intervention
• patients with a history of surgery in the gastrointestinal system in the past two weeks history of extrapyramidal manifestations
• patients with electrolyte imbalance
• pregnant patients,