A study comparing the effect of two doses of neostigmine on the gastric residual volume in critically ill patients on enteral feeding.

Participants were categorized into three groups: Group I and Group II received neostigmine 1 mg and 2 mg, respectively, and a control group received 10 ml of normal saline. All participants received an intravenous administration of 10 mg of metoclopramide. GRV was measured every 3 hours before enteral feeding. aspiration through nasogastric (NG) or orogastric (OG) tubes was done before the next due bolus of feeding.

Inclusion Criteria:

• patients with a GRV >120ml
• a normal heart rateExclusion Criteria
• absence of comorbidities such as diabetes and renal failure. exclusion Criteria:
• Patients exhibiting new-onset arrhythmias or heart block
• hypotension (systolic blood pressure less than 60 mmHg)
• experiencing active gastrointestinal bleeding or receiving prokinetic medications 8-12 hours before the intervention
• patients with a history of surgery in the gastrointestinal system in the past two weeks history of extrapyramidal manifestations
• patients with electrolyte imbalance
• pregnant patients,

The study included 124 patients aged between 20 and 60 years requiring enteral feeding via nasogastric (NG) or orogastric (OG) tubes