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The aim of this study is to evaluate the prokinetic effect of metoclopramide on gastric emptying in critically ill mechanically ventilated patients .
More than 50% of patients in ICU have gastric dysmotility, which leads to slow gastric emptying(GE) and high gastric residual volume (GRV) and is associated with increased mortality in these patients
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Metoclopramide group | Experimental | Patients will receive 10 mg intravenous metoclopramide / 6 hours. |
|
| Control group | Placebo Comparator | Patients will receive the same volume of intravenous placebo / 6 hours. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Metoclopramide | Drug | Cases will receive 10 mg intravenous metoclopramide every 6 hours. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Assessment of the risk of aspiration | Aspiration risk will be categorized using the system proposed by Ven de Putte and Perlas. As:
| 8 hours interval during first 5 days of enteral feeding |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of ventilator associated pneumonia | Pneumonia will be defined according to the ATS/IDSA clinical criteria and will be diagnosed if a new or progressive radiographic infiltrate is present and at least two of the three following clinical features are also present: (1) fever higher than 38°C, (2) leukocytosis or leucopenia and (3) purulent secretions. No microbiological confirmation is required for diagnosis of pneumonia. Infectious Diseases. Society of America (IDSA) and the American Thoracic. Society (ATS) |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tanta University Hospitals | Tanta | ElGharbiaa | 31527 | Egypt |
Data will be available upon reasonable request from the corresponding author
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| ID | Term |
|---|---|
| D008787 | Metoclopramide |
| ID | Term |
|---|---|
| D001549 | Benzamides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D062366 | para-Aminobenzoates |
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The drugs will be prepared by a dedicated anesthesiologist who is aware of the allocated group and will have no subsequent role in the study.
| Placebo | Drug | Cases will receive the same volume of IV placebo / 6 hours. |
|
| 8 hours interval during first 5 days of enteral feeding |
| Time of weaning from mechanical ventilation | Time of weaning from mechanical ventilation From the start of enteral feeding | From the start of enteral feeding till intensive care discharge through study completion, an average of 6months |
| Hospital stay | Hospital stay including intensive care and ward. | From the start of enteral feeding till intensive care discharge through study completion, an average of 6months |
| D062365 |
| Aminobenzoates |
| D001565 | Benzoates |
| D000146 | Acids, Carbocyclic |
| D002264 | Carboxylic Acids |
| D002723 | Chlorobenzoates |
| D062425 | Hydroxybenzoate Ethers |
| D062385 | Hydroxybenzoates |
| D006880 | Hydroxy Acids |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D010647 | Phenyl Ethers |
| D010636 | Phenols |