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The investigators are going to conduct a prospective observational cohort study in pediatric patients aged 28 days to 14 years old scheduled for elective cardiac surgery with cardiopulmonary bypass. The primary purpose of this study is to explore the effect of preoperative sleep disturbance on the incidence of postoperative delirium. Sleep status will be assessed using the Brief Infant Sleep Questionnaire(BISQ) and Children's Sleep Habits Questionnaire (CSHQ), and postoperative delirium status will be evaluated by Cornell assessment of pediatric delirium(CAPD). During the peri-operative period, children will wear actigraphs to record their sleep parameters.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Children scheduled to undergo elective congenital heart disease repair surgery with CPB |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| This is a observational study and there is no intervention. | Other | This is a observational study and there is no intervention. |
|
| Measure | Description | Time Frame |
|---|---|---|
| The incidence of postoperative delirium | Postoperative 7 days |
| Measure | Description | Time Frame |
|---|---|---|
| The proportions of subtypes of postoperative delirium( hypoactive, hyperactive, and mixed). | Postoperative 7 days | |
| Pain defined by the Face, Legs, Activity, Cry, and Consolability scale | The FLACC scale is a simple and effective tool used to assess pain in infants and non-verbal patients. It stands for Face, Legs, Activity, Cry, and Consolability. Each of these five items is scored on a scale of 0 to 2, with a higher score indicating a greater degree of pain. The total FLACC score, ranging from 0 to 10, provides a quick and reliable assessment of the patient's pain level. |
| Measure | Description | Time Frame |
|---|---|---|
| Concentration of plasma intestinal injury markers | Intestinal fatty acid binding protein, Zonulin, Lipopolysaccharide and so on. | Before surgery and 24 hours after surgery |
| Concentration of plasma blood-brain barrier injury markers |
Inclusion Criteria:
Exclusion Criteria:
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Pediatric patients aged more than 28 days and less than 14 years old who are scheduled to undergo elective corrective surgery for congenital heart disease under cardiopulmonary bypass.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Fuxia Yan | Contact | 01088396628 | yanfuxia@sina.com |
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| ID | Term |
|---|---|
| D000071257 | Emergence Delirium |
| D020447 | Parasomnias |
| D006330 | Heart Defects, Congenital |
| ID | Term |
|---|---|
| D003693 | Delirium |
| D003221 | Confusion |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
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Plasma
| Postoperative 7 days |
| The incidence of postoperative Acute kidney injury | Within postoperative 7 days. |
| Pulmonary complication | Postoperative 7 days |
| The incidence of postoperative Liver dysfunction | Postoperative 7 days |
| The duration of postoperative mechanical ventilation | The total hours needing mechanical ventilation support | From the end of the surgery to discharge from the hospital,up to 30 days. |
| The length of intensive care unit stay | The time spent in the intensive care unit. | From the end of the surgery to discharge from the hospital, up to 30 days. |
| The length of postoperative hospital stay | From the end of the surgery to the day of discharge from the hospital, up to 30 days.. |
| Before surgery and 24 hours after surgery |
| Concentration of plasma inflammatory factors. | The inflammatory cytokines include IL-6,TNF-α,IL-1β,IFN-γ,IL-17, C-reactive protein. | Before surgery and 24 hours after surgery |
| Types and total dosages of sedative and analgesic medications | From the start of the surgery to discharge from the hospital, up to 30 days. |
| D009422 |
| Nervous System Diseases |
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D012893 | Sleep Wake Disorders |
| D018376 | Cardiovascular Abnormalities |
| D002318 | Cardiovascular Diseases |
| D006331 | Heart Diseases |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |