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The goal of this study is to learn how a supplement Quercetin can affect microvascular function.
Participants will:
Researchers will compare blood vessel function of those who take estrogen supplements to those who do not.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Use of oral quercetin to improve human microvascular function | Experimental | Quercetin is a non-FDA approved, over-the-counter supplement that has been shown to improve oxidative capacity in blood vessels. |
|
| Placebo | Placebo Comparator | A placebo will be administered for 30 days followed by assessment of the subject's microvascular function. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Quercetin (dietary supplement) | Dietary Supplement | Quercetin will be provided to take one Quercetin per day for 30 days to look for differences in microvascular function. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in blood vessel dilation | Peripheral microvascular dilation in response to acetylcholine, L-NAME, and sodium nitroprusside infusions will be measured using laser Doppler flowmetry with microdialysis. | 2 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Perfused Vessel Density | Total vessel density (TVD) will be calculated using the DeBacker Score manual analysis on all images that have a minimum microcirculation image quality score (MIQS) of 10. Perfused vessel density (PVD) will be calculated by multiplying total vessel density (TVD) x proportion of perfused vessels (PPV%). | 0.5 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Julia A Vogt | Contact | 4149552348 | jvogt@mcw.edu |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Froedtert Hospital | Wauwatosa | Wisconsin | 53226 | United States |
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| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
| D009765 | Obesity |
| D050177 | Overweight |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
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| ID | Term |
|---|---|
| D011794 | Quercetin |
| D019587 | Dietary Supplements |
| ID | Term |
|---|---|
| D044948 | Flavonols |
| D005419 | Flavonoids |
| D002867 | Chromones |
| D001578 | Benzopyrans |
| D011714 |
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Subjects will be randomized to receive the supplement quercetin or placebo for 30 days to determine its effect on microvascular function.
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| Placebo | Drug | Subjects randomized to receive placebo will be administered a standard placebo sugar pill. |
|
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| Pyrans |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |