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| Name | Class |
|---|---|
| University of Geneva, Switzerland | OTHER |
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The investigators will measure blood levels of 1,5-anhydroglucitol in obese children with or without type 2 diabetes and correlate them with parameters related to functional beta-cell mass and glucose metabolism. The values will be compared to those obtained in healthy volunteers. The aim of the study is to test the validity of 1,5-anhydroglucitol as a novel biomarker of beta-cell mass and function in children with obesity with or without type 2 diabetes.
One-center prospective study performed in collaboration between the Pediatric Endocrine and Diabetology unit of the University Hospitals of Geneva (HUG) and Prof. Pierre Maechler, Diabetes Center of the Faculty of Medicine, University of Geneva Switzerland.
1,5-anhydroglucitol (1,5-AG), a deoxyhexose present in almost all foods and forming a stable pool in human subjects, has recently been found to be correlated with functional beta-cell mass in two different mouse models of beta-cell dysfunction leading to diabetes. The decline of this biomarker precedes the development of hyperglycemia in lean b-Phb2 -/- and obese db/db diabetic mice, where beta-cell loss occurs through two different mechanisms.
Additional studies have shown a correlation of 1,5-AG levels with risk of progression of type 1 diabetes (T1DM) in auto-antibody positive children, as well as with glycaemic control in patients with type 2 diabetes (T2DM).
The present project will analyse the correlation between functional beta-cell mass and the circulating levels of 1,5-AG in children with obesity with or without T2DM. This should contribute to the evaluation of a novel biomarker of beta-cell mass and function in T2DM.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Children with obesity | Children with obesity followed within the pediatric endocrine and diabetes unit of the University Hospitals of Geneva, Switzerland. The investigators will do prospective measures in 50 children aged 12 to 15 years, at the time of a planned oral glucose tolerance test and again, 2 years later. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Measurement of biomarker | Other | Measurement of blood levels of 1,5-anhydroglucitol |
|
| Measure | Description | Time Frame |
|---|---|---|
| Correlation of 1,5-anhydroglucitol levels in obese children with indirect markers of beta-cell function and mass and with metabolic control | Blood levels of 1,5-anhydroglucitol will be correlated with indirect markers of beta-cell function at 2 timepoints | First oral glucose tolerance test |
| Correlation of 1,5-anhydroglucitol levels in obese children with indirect markers of beta-cell function and mass and with metabolic control | Blood levels of 1,5-anhydroglucitol will be correlated with indirect markers of beta-cell function at 2 timepoints | Second oral glucose tolerance test, 2 years after the first |
| Measure | Description | Time Frame |
|---|---|---|
| Blood levels of 1,5-anhydroglucitol will be correlated with indicators of the liver function at different moments after diagnosis | Blood levels of 1,5-anhydroglucitol will be correlated with indicators of the liver function at 2 timepoints | First oral glucose tolerance test |
| Blood levels of 1,5-anhydroglucitol will be correlated with indicators of the liver function at different moments after diagnosis |
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Inclusion Criteria:
Exclusion Criteria:
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50 obese children aged 12 to 16 years who have a normal or altered glucose metabolism.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Philippe Klee | Contact | +41 79 55 33 476 | philippe.klee@unige.ch | |
| Pierre Maechler | Contact | pierre.maechler@unige.ch |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital of Geneva | Recruiting | Geneva | Canton of Geneva | 1211 | Switzerland |
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| ID | Term |
|---|---|
| D063766 | Pediatric Obesity |
| ID | Term |
|---|---|
| D009765 | Obesity |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
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Blood levels of 1,5-anhydroglucitol will be correlated with indicators of the liver function at 2 timepoints |
| Second oral glucose tolerance test, 2 years after the first |
| D009750 |
| Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |