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| Name | Class |
|---|---|
| American Heart Association | OTHER |
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This research study aims to understand the relationship between brain stimulation and leg skill learning in both healthy adults and persons with chronic stroke.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Explore the effects of brain stimulation on locomotor skill learning in stroke survivors | Experimental | To explore the trends of locomotor skill learning in three groups: stroke survivors after five sessions of anodal tDCS (a-tDCS, real brain stimulation), stroke survivors after five sessions of sham tDCS (s-tDCS), and stroke survivors with no brain stimulation (control; CON). |
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| determine the effects of a-tDCS on the cortical excitation before and after locomotor learning | Experimental | measure changes in cortical neuronal activation before and after five sessions of locomotor skill training in healthy adults and stroke participants. |
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| To explore improvements in learning capacity between healthy adults and stroke participants. | Experimental | Compare stimulation-induced improvements in learning capacity between three groups: stroke group, healthy young group, and healthy older group. |
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| To explore the trends of functional improvements after five tDCS session in stroke survivors | Experimental | Compare functional improvements (gait performance, balance, motor and cognitive function) between healthy adults and stroke participants after five sessions of brain stimulation. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| anodal transcranial direct current stimulation (a-tDCS) | Combination Product | Stroke participants will be randomly assigned into one of three groups: anodal transcranial direct current stimulation (a-tDCS), sham tDCS (s-tDCS), or control groups (i.e. no brain stimulation). Stroke participants in the first two groups will receive five sessions of the assigned brain stimulation combined with visuomotor stepping training over five consecutive days. Healthy adults will be randomly assignments into a-tDCS or s-tDCS groups. |
| Measure | Description | Time Frame |
|---|---|---|
| Mean change from baseline in stepping motor control after five sessions of brain stimulation combined with visuomotor stepping learning | Stepping motor control will be quantified by the time (seconds) that each participant takes to initiate a forward step onto a visual target displayed on the wall screen. | Day 1, Day 5, Day 7, Day 30, Day 60, Day 9 post five sessions of brain stimulation combined with visuomotor stepping training |
| Mean change from baseline in brain neuronal activations after five sessions of brain stimulation combined with visuomotor stepping learning | The neuronal activations will be quantified by peak-to-peak electrical signals detected by surface electromyographic (EMG) electrodes on leg muscles after transcranial magnetic stimulations | Day 1, Day 5, Day 7, Day 30, Day 60, Day 9 post five sessions of brain stimulation combined with visuomotor stepping training |
| Measure | Description | Time Frame |
|---|---|---|
| Mean change from baseline in lower extremity (LE) motor function after five sessions of brain stimulation combined with visuomotor stepping learning | LE motor function will be quantified by Fugl-Meyer LE motor test, Short Physical Performance Battery (SPPB), and gait speed (meters/second) during ground walking tests. | Day 1, Day 5, Day 7, Day 30, Day 60, Day 9 post five sessions of brain stimulation combined with visuomotor stepping training |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Shih-Chiao Tseng, PT, PhD | Contact | 409--772-9555 | shtseng@utmb.edu |
| Name | Affiliation | Role |
|---|---|---|
| Shih-Chiao Tseng, PT, PhD | University of Texas | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Physical Therapy, University of Texas Medical Branch | Recruiting | Galveston | Texas | 77555 | United States |
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| ID | Term |
|---|---|
| D020521 | Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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| Mean change from baseline in brain neuronal network activations after five sessions of brain stimulation combined with visuomotor stepping learning | The neuronal activations will be quantified by oxygen consumption changes locally detected by surface infrared diodes | Day 1, Day 5, Day 7, Day 30, Day 60, Day 9 post five sessions of brain stimulation combined with visuomotor stepping training |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |