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| ID | Type | Description | Link |
|---|---|---|---|
| R01HD075777 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | NIH |
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Over four million stroke survivors currently living in the United States are unable to walk independently in the community. To increase the effectiveness of gait rehabilitation, it is critical to develop therapies that are based on an understanding of brain adaptations that occur after stroke. This project will be the first step towards the development of a novel therapeutic approach using brain stimulation to increase walking capacity in stroke survivors and understand the neural mechanisms that are associated with impairment and functional recovery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| tDCS+AMT | Experimental | TDCS in combination with movement training before treadmill training |
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| tDCS | Active Comparator | tDCS only before treadmill training |
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| AMT | Active Comparator | Movement training only before treadmill training |
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| Control | Sham Comparator | No priming before treadmill training |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| tDCS | Other | 1 mA of tDCS |
| |
| AMT |
| Measure | Description | Time Frame |
|---|---|---|
| Change in gait speed using 10 meter walk test | 10-meter walk test: Gait speed will be measured as the average of 3 trials of the 10-m walk test. Participants will be asked to walk at their normal comfortable pace to cover a distance of 10 meters without an AFO (handheld assistive device is acceptable if needed). | Change from baseline to immediately after training and baseline to 3 months follow up |
| Measure | Description | Time Frame |
|---|---|---|
| Change in 6 minute walk test | The 6 Minute Walk Test is a sub-maximal exercise test used to assess aerobic capacity and endurance. Participants will be asked to walk at their normal pace for 6 minutes. | Change from baseline to immediately after training and baseline to 3 months follow up |
| Change in Berg Balance Scale |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sangeetha Madhavan | UIC | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The University of Illinois at Chicago | Chicago | Illinois | 60612-7246 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32799922 | Derived | Madhavan S, Cleland BT, Sivaramakrishnan A, Freels S, Lim H, Testai FD, Corcos DM. Cortical priming strategies for gait training after stroke: a controlled, stratified trial. J Neuroeng Rehabil. 2020 Aug 17;17(1):111. doi: 10.1186/s12984-020-00744-9. |
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| ID | Term |
|---|---|
| D020521 | Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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| Other |
Ankle motor training |
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| Treadmill training | Behavioral | High intensity treadmill training |
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Balance will be measured using the Berg Balance Scale. It is a 14 item list with each item consisting of a five-point ordinal scale ranging from 0 to 4, with 0 indicating the lowest level of function and 4 the highest level of function. Tasks such as standing with eyes closed, one leg stance etc are included. |
| Change from baseline to immediately after training and baseline to 3 months follow up |
| Change in Quality of life measures | QOL will be measured with the Stroke Impact Scale (SIS). The SIS is a stroke-specific self-reported health status measure. | Change from baseline to immediately after training and baseline to 3 months follow up |
| Change in cortical excitability of leg muscles using TMS | Transcranial magnetic stimulation will be used to measure contralateral and ipsilateral corticospinal excitability of the paretic tibialis anterior (TA) using the protocol previously published by the PI Dr. Madhavan. | Change from baseline to immediately after training and baseline to 3 months follow up |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |