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The goal of this observational study is to learn the factors affecting the quality of life in children's development.
The main hypothesis for this study is:
If the level of well-being increases in age, could the quality of life be enhanced in terms of function and participation?
Participant will be given assessment every year for five years in total. No intervention will be given during the whole study period.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normal Developing Children | Children that were satisfied with the criteria as average or "on-time" growth based on the attainment of specific physical, cognitive, linguistic, social-emotional, and behavioral milestones across specific stages. | ||
| Developmental Delay Children | Children who has not gained the developmental skills expected of him or her, compared to others of the same age. |
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| Measure | Description | Time Frame |
|---|---|---|
| Score of participation (< 3y) | Children Assessment of Participation and Enjoyment and Preferences for Activity of Children (Higher scores means a better outcome.) | baseline |
| Score of participation (3y > 15y) | Pediatric Quality of Life Inventory TM (Scores from 0 to 102, higher scores mean a better outcome.) | Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Gene Test | Whole-Exome Sequencing (Use Burrows-Wheeler Aligner (BWA) 85, Samtools86, Picard, Genome Analysis Toolkit (GATK) to screen out the variant discovery and genotyping.) | Baseline |
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Normal developing children
Inclusion Criteria:
Exclusion Criteria:
Development delay children
Inclusion Criteria:
Exclusion Criteria:
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Control and experimental group
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| Name | Affiliation | Role |
|---|---|---|
| Chia-Ling Chen, MD,PhD | Chang Gung Memorial Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chang Gung Memorial Hospital | Taoyuan | 333 | Taiwan |
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| ID | Term |
|---|---|
| D007859 | Learning Disabilities |
| ID | Term |
|---|---|
| D003147 | Communication Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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Samples with DNA
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |