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This project adopts a prospective study design. It is scheduled to enroll 60 participants diagnosed with Head and Neck cancer in this hospital, of which 30 are in the experimental group and 30 are in the control group. The purpose of this research is to analyze the skeletal muscle mass changes on images in Head and Neck cancer patients after exercise training and the association with systemic inflammatory markers. Investigators would like to know whether these images and biomarkers predict the prognosis of Head and Neck cancer. Subjects enrolled in the trial will receive 36 times of exercise training after concurrent chemoradiotherapy. Before and after the completion of exercise training, investigators will arrange (1) dual energy X-ray absorptiometry (DXA) to measure the whole-body skeletal muscle mass and appendicular skeletal muscle mass and (2) blood tests for markers of systemic inflammation. In addition to DXA, computed tomography (CT) is another image modality for skeletal muscle mass evaluation. Positron emission tomography - CT or whole-body CT for cancer staging are considered as baseline studies. The routine follow-up CT images are used to analyze the changes after exercise training. If magnetic resonance imaging is also performed during the follow-up period, images will also be collected and assessed as an alternative.If the experimental group can maintain or even improve skeletal muscle mass and can be reflected in blood tests and prognosis, the result may be able to apply on cancer treatment and disease followup.
This project adopts a prospective study design. It is scheduled to enroll 60 patients diagnosed with Head and Neck cancer in this hospital, of which 30 are in the experimental group and 30 are in the control group. The purpose of this research is to analyze the skeletal muscle mass changes on images in Head and Neck cancer participants after exercise training and the association with systemic inflammatory markers. Investigators would like to know whether these images and biomarkers predict the prognosis of head and neck cancer. Subjects enrolled in the trial will receive 36 times of exercise training after concurrent chemoradiotherapy. Before and after the completion of exercise training, investigators will arrange (1) dual energy X-ray absorptiometry (DXA) to measure the whole-body skeletal muscle mass and appendicular skeletal muscle mass and (2) blood tests for markers of systemic inflammation. In addition to DXA, computed tomography (CT) is another image modality for skeletal muscle mass evaluation. Positron emission tomography - CT or whole-body CT for cancer staging are considered as baseline studies. The routine follow-up CT images are used to analyze the changes after exercise training. If magnetic resonance imaging is also performed during the follow-up period, images will also be collected and assessed as an alternative. If the experimental group can maintain or even improve skeletal muscle mass and can be reflected in blood tests and prognosis, the result may be able to apply on cancer treatment and disease follow-up.
This project can determine the baseline skeletal muscle mass of Head and Neck cancer patients and hope to monitor its changes after exercise training through imaging tools and find the most suitable imaging modalities. To understand the role of systemic inflammatory markers in sarcopenia, exercise training and oral cancer prognosis. This study hopes to serve as a basis and reference for clinical treatment selection, imaging follow up, interventional treatment or rehabilitation. The results of this research should benefit participants in Taiwan and abroad, and to promote the medical treatment and health of participants.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control | No Intervention | No Intervention: Head and Neck patients after CCRT treatment. After CCRT treatment, participants keep follow the skeletal muscle mass evaluation | |
| experimental | Experimental | Experimental: Head and Neck patients after CCRT treatment with exercise training. After CCRT treatment 4-5 week, arrange participants do the exercise training for patient. Two to three times a week ,total 24-36 times. Participants keep follow the skeletal muscle mass evaluation. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| HIIT only | Other | After CCRT treatment 4-5 week, arrange participants do the HIIT exercise for two to three times a week and total 24-36 times. |
|
| Measure | Description | Time Frame |
|---|---|---|
| dual energy X-ray absorptiometry data | measure the whole-body skeletal muscle mass | baseline,pre-iprocedure |
| dual energy X-ray absorptiometry data | measure the whole-body skeletal muscle mass | 3 month, during procedure |
| dual energy X-ray absorptiometry data | measure the whole-body skeletal muscle mass | 8 month, during procedure |
| Measure | Description | Time Frame |
|---|---|---|
| Cardiopulmnary Exercise Test | record the VO2% of participants by doing the exercise test to assess the cardiopulmnary funtion before and after excercise training | baseline,pre-iprocedure |
| Cardiopulmnary Exercise Test |
| Measure | Description | Time Frame |
|---|---|---|
| computed tomography (CT) | check toumor condition and another image modality for skeletal muscle mass evaluation | baseline,pre-iprocedure |
| computed tomography (CT) | check toumor condition and another image modality for skeletal muscle mass evaluation |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Shao-Chung Wang, PhD | Contact | 0978835190 | seanscwang@cgmh.org.tw | |
| Chia-Hsun Hsieh, PhD | Contact | 0975366137 | wisdom5000@cgmh.org.tw |
| Name | Affiliation | Role |
|---|---|---|
| Shao-Chung Wang | New Taipei City TuCheng Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| New Taipei City TuCheng Hospital | Recruiting | New Taipei City | Taiwan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29151281 | Background | Tieland M, Trouwborst I, Clark BC. Skeletal muscle performance and ageing. J Cachexia Sarcopenia Muscle. 2018 Feb;9(1):3-19. doi: 10.1002/jcsm.12238. Epub 2017 Nov 19. |
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| ID | Term |
|---|---|
| D006258 | Head and Neck Neoplasms |
| D055948 | Sarcopenia |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
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This project can determine the baseline skeletal muscle mass of Head and Neck cancer patients and hopes to monitor its changes after exercise training through imaging tools and find the most suitable imaging modalities. To understand the role of systemic inflammatory markers in sarcopenia,exercise training and Head and Neck cancer cancer prognosis. This study hopes to serve as a basis and reference for clinical treatment selection, imaging follow up, interventional treatment or rehabilitation. The results of this research should benefit patients in Taiwan and abroad, and to promote the medical treatment and health of patients.
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group random
| HIIT & Record of physical activities at home. | Other | After CCRT treatment 4-5 week, arrange participants do the HIIT exercise for two to three times in a week and total 24-36 times. And do the recording of physical activities at home. |
|
record the VO2% of participants by doing the exercise test to assess the cardiopulmnary funtion before and after excercise training
| 3 month, during procedure |
| Cardiopulmnary Exercise Test | record the VO2% of participants by doing the exercise test to assess the cardiopulmnary funtion before and after excercise training | 8 month, during procedure |
| 8 month, during procedure |
| blood data-myostatin | inflammatory markers | 3 month, during procedure |
| blood data-myostatin | inflammatory markers | 8 month, during procedure |
| blood data-IL-10 | inflammatory markers | 3 month, during procedure |
| blood data-IL-10 | inflammatory markers | 8 month, during procedure |
| blood data-IL-1β | inflammatory markers | 3 month, during procedure |
| blood data-IL-1β | inflammatory markers | 8 month, during procedure |
| blood data-IL-15 | inflammatory markers | 3 month, during procedure |
| blood data-IL-15 | inflammatory markers | 8 month, during procedure |
| D009461 |
| Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |