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Head and neck cancer patients often experience a critical weight loss of around 10% following radiation therapy. Of this up to 70% is muscle mass and is an independent predictor of mortality, lowers muscle strength and functional performance. The purpose of this study is in a randomized controlled trial to investigate the effects of progressive resistance training (PRET) on changes in muscle mass, muscle strength and functional performance in head and neck cancer survivors. The investigators hypothesize that PRET has a positive effect on all primary endpoints and increases muscle mass, muscle strength and functional performance.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Early training patient | Experimental | 12 weeks of Progressive Resistance Training followed by 12 weeks of a self chosen level of physical activity |
|
| Late training patients | Experimental | 12 weeks of a self chosen level of physical activity followed by 12 weeks of progressive resistance training |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Progressive Resistance Exercise Training | Other | 12 weeks of Progressive Resistance Exercise Training followed by 12 weeks of self chosen training |
|
| Measure | Description | Time Frame |
|---|---|---|
| Body composition | Lean body mass and fat mass assessed by DEXA scanning | Baseline, 3 months and 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Maximal muscle strength | Isometric and isokinetic muscle dynamometry | Baseline, 3 months and 6 months |
| Maximal gait speed | 10 m walk time |
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Inclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jens Overgaard, Prof., MD | Danish Head and Neck Cancer Group | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dept. of Experimental Clinical Oncology | Aarhus C | 8000 | Denmark |
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| Label | URL |
|---|---|
| The website for the Danish Head and Neck Cancer Group (DAHANCA). | View source |
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| Progressive Resistance Exercise Training | Other | 12 weeks of self chosen training followed by 12 weeks of progressive resistance exercise training |
|
| Baseline, 3 months and 6 months |
| Patient reported outcomes | Questionaires on Quality of Life, Fatigue and Mood | Baseline, 3 months and 6 months |
| Blood sampling | Investigation of changes in serum level of markers related to weight loss, inflammation and muscle hypertrophy | Baseline, 3 months and 6 months |
| 30 s arm curl capacity | Baseline, 3 months, 6 months |
| Stair climbing capacity | Baseline, 3 months, 6 months |
| Jumping capacity | Counter Movement Jumps | Baseline, 3 months, 6 months |
| Chair rise capacity | 30 s chair rise | Baseline, 3 months, 6 months |
| ID | Term |
|---|---|
| D006258 | Head and Neck Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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