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| ID | Type | Description | Link |
|---|---|---|---|
| CIRRO-IP010309 | Other Grant/Funding Number | CIRRO | |
| Ethical Comittee: 20090181 |
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| Name | Class |
|---|---|
| Danish Center for Interventional Research in Radiation Oncology (CIRRO) | OTHER |
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The purpose of this study is to investigate whether resistance training in combination with dietary supplementation is tolerable among head and neck cancer patients and to evaluate the possible effect on muscle mass, strength and functional capacity.
Head and neck cancer patients experience a significant loss of muscle mass following radiotherapy treatment due to cachexia and dysphagia. This negatively affects muscle strength and functional capacity.
Studies on healthy individuals and various groups of patients show that resistance training in combination with protein and creatine ingestion is an effective means of increasing muscle mass, strength and functional capacity.
Thus the aim is to investigate the following:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| resistance training and dietary supplement | Experimental |
| |
| Resistance training and placebo ingestion | Placebo Comparator | 12 weeks of resistance training and placebo ingestion |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Resistance training | Other | 12 weeks of resistance training in combination with protein and creatine or placebo ingestion |
|
| Measure | Description | Time Frame |
|---|---|---|
| Muscle mass and muscle strength | 13 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Functional capacity | 13 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jens Overgaard, Professor, MD | DAHANCA | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dept. of Experimental Clinical Oncology, Aarhus University Hospital | Aarhus | Region Midt | 8000 | Denmark | ||
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| Label | URL |
|---|---|
| Danish Head and Neck Cancer Group | View source |
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| Protein and creatine | Dietary Supplement | 30 g of protein with each training session, 5 g of creatine pr day |
|
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| Placebo | Dietary Supplement | Maltodextrine |
|
| Dept. of Experimental Clinical Oncology |
| Aarhus |
| 8000 |
| Denmark |
| ID | Term |
|---|---|
| D006258 | Head and Neck Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| D055070 | Resistance Training |
| D011506 | Proteins |
| D003401 | Creatine |
| ID | Term |
|---|---|
| D005081 | Exercise Therapy |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
| D005791 | Patient Care |
| D013812 | Therapeutics |
| D026741 | Physical Therapy Modalities |
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
| D000602 | Amino Acids, Peptides, and Proteins |
| D006146 | Guanidines |
| D000578 | Amidines |
| D009930 | Organic Chemicals |
| D000596 | Amino Acids |
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