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The goal of this observational study is to analyze the acute effects of meteorological factors and air pollution on cardiovascular system. The main question it aims to answer is:
Participants will:
The collected data include: ID number (or unique identification code similar to ID number), physical examination date, work unit, occupation, gender, age, systolic blood pressure, diastolic blood pressure, height, weight, blood routine, urine routine and blood biochemical examination results,Color Doppler (or B-ultrasound) examination results (thyroid color Doppler, abdominal color Doppler, urinary color Doppler, cardiac color Doppler, cervical vascular color Doppler, etc.), electrocardiogram, cardiac CTA, carbon 13 breath test, and written diagnosis results of liver fibrosis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High Temperature Group | Participants experiencing temperatures above the 90th percentile for the region, as recorded during the summer months. Temperature data are sourced from local meteorological statio |
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| Low Temperature Group | Includes participants from areas where winter temperatures are below the 10th percentile, based on historical weather data from local meteorological observations |
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| High Pollution Group | Participants in this group are those exposed to high levels of air pollutants |
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| Low Pollution Group | This cohort consists of individuals living in areas with air pollutant levels consistently below the national air quality standards |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| NOT | Other | This retrospective cohort study involves no new interventions. It analyzes existing health data collected from subjects exposed to varying atmospheric conditions to assess impacts on health outcomes. |
| Measure | Description | Time Frame |
|---|---|---|
| Troponin | Troponin data were obtained by blood biochemical detection data recorded in the diagnosis and treatment system, with unit of µg/L. | The troponin data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure. |
| Blood pressure | Blood pressure data were obtained from the diagnosis and treatment record system and analyzed by standard sphygmomanometer, with unit of mmHg. | The blood pressure data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure. |
| Measure | Description | Time Frame |
|---|---|---|
| Left ventricular ejection fraction（LVEF） | Left ventricular ejection fraction（LVEF）data were obtained by Cardiac color ultrasound data recorded in the diagnosis and treatment system, with unit of % | The left ventricular ejection fraction（LVEF）data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure. |
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Inclusion Criteria:
·Relevant records in the physical examination database shall be ≥3 times
·≥18 years old
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mingwei W Wang, PhD | Contact | 18758871517 | not | wmw990556@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| MingWei Wang | Recruiting | Hanzhou | Zhejiang | 310000 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 12802026 | Background | Clement DL, De Buyzere ML, De Bacquer DA, de Leeuw PW, Duprez DA, Fagard RH, Gheeraert PJ, Missault LH, Braun JJ, Six RO, Van Der Niepen P, O'Brien E; Office versus Ambulatory Pressure Study Investigators. Prognostic value of ambulatory blood-pressure recordings in patients with treated hypertension. N Engl J Med. 2003 Jun 12;348(24):2407-15. doi: 10.1056/NEJMoa022273. | |
| 10791531 |
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| White cell count | White cell count data were obtained by blood routine blood data recorded in the diagnosis and treatment system, with unit of 10^9/L | The white cell count data were tested at baseline 3 months before exposure to meteorological factors or air pollution, and followed up for 1 year and 2 years after exposure. |
| Controlled Attenuation Parameter（CAP） | Controlled Attenuation Parameter（CAP）data were obtained by Diagnosis of hepatic fibrosis data recorded in the diagnosis and treatment system, with unit of dB/m. | The Controlled Attenuation Parameter（CAP）data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure. |
| ST segment of electrocardiogram | ST segment were obtained by Electrocardiogram (ECG) recorded in the diagnosis and treatment system with unit of mV. | The ST segment of electrocardiogram were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure. |
| Degree of coronary artery stenosis | Degree of coronary artery stenosis data were obtained by Coronary CTA data recorded in the diagnosis and treatment system, with unit of µg/L | The degree of coronary artery stenosis data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure. |
| Weight | Weight data were obtained from the diagnosis and treatment record system and recorded by standard measuring tools, with unit of kg | The weight data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure. |
| Height | Height data were obtained from the diagnosis and treatment record system and recorded by standard measuring tools, with unit of cm | The height data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure. |
| Urinary glucose | Urinary glucose data were obtained by Urine routine data recorded in the diagnosis and treatment system, with unit of mmol/L. | The urinary glucose data were tested at baseline 3 months before exposure tometeorological factors or air pollution, and followed up for 1 year and 2 years after exposure. |
| Background |
| McCarron P, Smith GD, Okasha M, McEwen J. Blood pressure in young adulthood and mortality from cardiovascular disease. Lancet. 2000 Apr 22;355(9213):1430-1. doi: 10.1016/S0140-6736(00)02146-2. |
| 36265590 | Background | Tandon S, Grande AJ, Karamanos A, Cruickshank JK, Roever L, Mudway IS, Kelly FJ, Ayis S, Harding S. Association of Ambient Air Pollution with Blood Pressure in Adolescence: A Systematic-review and Meta-analysis. Curr Probl Cardiol. 2023 Feb;48(2):101460. doi: 10.1016/j.cpcardiol.2022.101460. Epub 2022 Oct 18. |