Will the use of bone marrow stem cells with platelet rich fibrin enhance and accelerate the bone regeneration in the upper jaw cystic defects ?

Reconstruction of critical size bone defect in maxillofacial surgery is a great challenge, current practice of bone reconstruction still having problems like delay in bone regeneration (up to 12 months) and bone graft failure and low availability of autogenous bone graft.

last decade stem cells therapy gained great interest, in many studies Bone marrow stem cells showed promising result in bone regeneration enhancing .

Platelet Rich Fibrin PRF also capability of enhancing bone and tissue regeneration by releasing of certain protein molecules call growth factors that initiate sequential biological events resulting in stem cells migration into the site of bone defect and differentiation to bone formation cells (osteoblast cells ).

Inclusion Criteria:

• Age range 18-50 years
• Patients with a critical size maxillary cyst. (>3 cm)
• Patients that free of any significant medical conditions that could affect healing or outcomes.

Exclusion Criteria:

• Patients with large jaw cyst that endanger vital structures
• Patients with significant medical condition
• age under 18 years