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Establish a cohort of diabetic kidney disease(DKD) patients with intensive weight loss treatment to evaluate the impact of intensive weight loss treatment on the renal prognosis of DKD and construct a prediction model for the improvement of renal outcomes after weight loss.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Surgical group |
| ||
| Non-surgical group |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Bariatric surgery | Procedure | Laparoscopic sleeve gastrectomy or laparoscopic gastric bypass based on β-cell function |
|
| Measure | Description | Time Frame |
|---|---|---|
| Total weight loss | 1st, 3rd, 6th and 12th month after intervention, respectively. |
| Measure | Description | Time Frame |
|---|---|---|
| Serum creatinine | 1st, 3rd, 6th and 12th month after intervention, respectively. | |
| Glomerular filtration rate | 1st, 3rd, 6th and 12th month after intervention, respectively. | |
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Inclusion Criteria:
Age 18 to 65 years old;
BMI>25Kg/m2 or abdominal obesity (i.e. waist circumference>90cm for men and>85cm for women);
Exclusion Criteria:
Patients who are taking glucocorticoids;
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Obese patients with DKD treated with intensive weight loss or traditional treatment
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Nianrong Zhang | Contact | +86 188 1048 8650 | znrsd@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Hua Meng | China-Japan Friendship Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| China-Japan Friendship Hospital | Recruiting | Beijing | Beijing Municipality | China |
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| ID | Term |
|---|---|
| D003928 | Diabetic Nephropathies |
| ID | Term |
|---|---|
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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| ID | Term |
|---|---|
| D050110 | Bariatric Surgery |
| ID | Term |
|---|---|
| D049088 | Bariatrics |
| D000073319 | Obesity Management |
| D013812 | Therapeutics |
| D013514 | Surgical Procedures, Operative |
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| Non-surgical therapy | Other | Diet management，exercise，metformin，GLP-1 receptor agonists and other drugs which can lose weight. |
|
| Fasting blood glucose |
| 1st, 3rd, 6th and 12th month after intervention, respectively. |
| Average blood glucose from continuous glucose monitoring | 1st, 3rd, 6th and 12th month after intervention, respectively. |
| Postprandial 2-hour blood glucose | 1st, 3rd, 6th and 12th month after intervention, respectively. |
| HbA1c | 1st, 3rd, 6th and 12th month after intervention, respectively. |
| Waist circumference and hip circumference | 1st, 3rd, 6th and 12th month after intervention, respectively. |
| Urinary microalbumin and other Urinalysis indexes | 1st, 3rd, 6th and 12th month after intervention, respectively. |
| Medication status | 1st, 3rd, 6th and 12th month after intervention, respectively. |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D048909 | Diabetes Complications |
| D003920 | Diabetes Mellitus |
| D004700 | Endocrine System Diseases |