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| Name | Class |
|---|---|
| Jomo Kenyatta University of Agriculture and Technology | OTHER |
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Using standardized methods, the investigators will perform stable iron isotope absorption studies in young Kenyan women and their preschool children (2-5y of age) with varying iron status to measure iron absorption from maize meal containing labeled ferrous sulfate. Using these data, this study aim is to define the ferritin in these young women and children at which the body senses iron depletion and begins to upregulate iron absorption from the diet; this approach could provide a functionally defined threshold of iron deficiency in Sub-Saharan African women and children.
In this experimental study in southern Kenya, the investigators will take a baseline venous blood sample to measure iron and inflammation biomarkers in generally healthy young women (n=125) and in their preschool children. The investigators will then administer, after an overnight fast, a standardized test meal porridge made from refined maize and bottled water containing the stable iron isotope 57Fe. Fourteen days later, the investigators will take a second venous blood sample for determination of erythrocyte incorporation of the 57Fe to measure iron absorption from the labeled test meal.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| mothers | Other | healthy volunteers |
|
| preschool children | Other | healthy volunteers |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| consumption of maize porridge containing stable iron isotope | Other | consumption of maize porridge containing stable iron isotope |
|
| Measure | Description | Time Frame |
|---|---|---|
| Fractional iron absorption | Erythrocyte iron incorporation | Study day 14 |
| Measure | Description | Time Frame |
|---|---|---|
| Serum ferritin | Serum ferritin concentration | Study day 1 |
| soluble transferrin receptor | soluble transferrin receptor concentration in serum |
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Inclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| ETH/JKUAT Research Station | Msambweni | Kenya |
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| Study day 1 |
| C-reactive protein | C-reactive protein concentration in serum | Study day 1 |
| alpha(1)-acid-glycoprotein | alpha(1)-acid-glycoprotein concentration in serum | Study day 1 |