Probiotic Use for Recovery Enhancement From Long COVID-19

PURE-LC - Probiotic Use for Recovery Enhancement From Long COVID

The goal of this clinical trial is to learn if probiotics can improve symptoms and quality of life in participants with Long COVID.

The goal of this clinical trial is to learn if probiotics can improve symptoms and quality of life in participants with Long COVID. The main questions it aims to answer are:

1. Do probiotics reduce the number and severity of symptoms in those with Long COVID?
2. Do probiotics improve the physical and mental health quality of life in those with Long COVID?
3. Do probiotics improve return to work and daily activities in those with Long COVID?

Researchers will compare probiotics to a placebo (a look-alike substance that contains no probiotics) to see if probiotics work to treat Long COVID.

Participants will take the study medication (placebo or probiotic) for 4 months. They will then cross over (take the other medication) for an additional 4 months. Participants will complete a survey at baseline, 4 months, and 8 months.

Inclusion Criteria:

• Age ≥18 years who report Long COVID with persistent symptoms at the time of study initiation

Exclusion Criteria:

• No longer have symptoms consistent with LC
• Are unable to take the study medication daily
• Are currently pregnant or planning to become pregnant over the course of the study
• Are currently breastfeeding
• Have been diagnosed with an immune-compromising condition
• Are currently taking immunosuppressants
• Do not speak English as a primary language
• Are regularly taking probiotics
• Are enrolled in another Long COVID study with an intervention