Pre-probiotic Supplementation for Post-covid Fatigue Syndrome

The Effects of 3-month Supplementation With a Pre-probiotic on Patient- and Clinician-reported Outcomes, and Brain Tissue Metabolism in Patients With Post-covid Fatigue Syndrome: a Placebo-controlled Randomized Clinical Trial

The goal of this randomized controlled double-blind parallel-group interventional trial is to evaluate the effects of of dietary supplementation with a pre-probiotic on patient- and clinician-reported outcomes, and brain tissue metabolism in patients with post-covid fatigue syndrome.

Inclusion Criteria:

• Age 18 - 65 years
• Covid-19 positive test within last 3 months (as documented byvalid PCR or antigentest
• Moderate-to-severe fatigue (20-MFI test total score > 43.5)
• At least one of additional covid-19 related symptoms (anosmia,ageusia,breathingdifficulties,lungpain, body aches, headaches, difficulties concentrating etc.)

Exclusion Criteria:

• Other pulmonary and cardiovascular conditions
• History of dietary supplement use during the past 4 weeks
• Organic gastrointestinal (GI) disorders such as inflammatory bowel disease, coeliac disease, eosinophilic disorders, or current infection of the GI tract.
• Bowel surgery or short bowel syndrome.
• Medication or supplement which can impact the gut microbiome, including: antibiotics, antimicrobials, or antifungals in the two months
• Probiotic or prebiotic supplements in the last 4 weeks