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Compare the incidence of hypotension during the propofol-induced period between the internal jugular vein variability-guided fluid infusion group and the conventional fluid infusion group through a fluid infusion experiment before anesthesia induction, so as to evaluate the feasibility of using the internal jugular vein variability under deep inspiration to guide preoperative fluid infusion.
Ultrasound records at least one quiet breathing cycle and one deep inhalation cycle to calculate IJVV Propofol was infused target-controlled at 4 μg/ml, and changes in arterial blood pressure within 3 minutes of propofol induction were observed.
Plan to conduct a prospective randomized controlled study to compare the incidence of hypotension during the propofol-induced period between the internal jugular vein variability-guided fluid infusion group and the conventional fluid infusion group through a fluid infusion experiment before anesthesia induction.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Guiding rehydration group | Experimental | According to the 421 fluid replacement principle, preoperative fluid replacement is performed |
|
| Conventional rehydration group | Active Comparator | rehydrated within 15 minutes according to 0.2ml/kg/min. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Guiding rehydration | Behavioral | Preoperative fluid rehydration was performed according to 421 fluid rehydration principles |
|
| Measure | Description | Time Frame |
|---|---|---|
| The incidence of a 20% drop in blood pressure after propofol induction | The incidence of a 20% drop in blood pressure after propofol induction | 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Qinghe Zhou | Contact | 13732573379 | jxxmxy@163.com | |
| Xuelian Wei | Contact | 18133822661 | 2275076157@qq.com |
| Name | Affiliation | Role |
|---|---|---|
| Qinghe Zhou | Affiliated Hospital of Jiaxing University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Affiliated Hospital of University | Recruiting | Jiaxing | Zhejiang | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40676549 | Derived | Wei XL, Xi YZ, Xie L, Li ZP, Tang HL, Zhou QH. Effects of liquid resuscitation guided by internal jugular vein variability during deep inhalation on preventing propofol-induced hypotension in elderly patients. BMC Anesthesiol. 2025 Jul 17;25(1):350. doi: 10.1186/s12871-025-03227-3. |
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| ID | Term |
|---|---|
| D007022 | Hypotension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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