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| Name | Class |
|---|---|
| Shanghai Jiao Tong University School of Medicine | OTHER |
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A randomized, double-blind, sham-controlled unicenter clinical trial was used to investigate the effectiveness and neural mechanism of high-frequency repetitive transcranial magnetic stimulation in the treatment of upper limb bradykinesia in patients with Parkinson's disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| verum group | Experimental | verum group receive real 10 sessions of rTMS stimulation. once daily for 5 consecutive days a week. |
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| sham group | Sham Comparator | The sham group receives 10 sessions of rTMS stimulation, once daily for 5 consecutive days a week. However, a sham stimulation coil is used, which emits the same sound and vibration as the active coil but does not produce any induced electrical currents. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| high frequency-repetitive transcranial magnetic stimulation | Device | rTMS involves the repeated application of magnetic pulses to specific areas of the brain. These pulses are delivered using a coil placed on the scalp, which generates a magnetic field that induces electrical currents in the brain tissue. |
| Measure | Description | Time Frame |
|---|---|---|
| Unified Parkinson's Disease Rating Scale (MDS-UPDRS) | Change in Unified Parkinson's Disease Rating Scale (MDS-UPDRS) total score of part III from Day 1 to 1 year. The part III of the MDS-UPDRS assess motor function in best on phase. The score range is 0-132, where a higher score means more severe motor impairment. | 2 weeks and 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| cortical activation detected by fNIRS | Using near-infrared brain imaging systems, have patients perform finger tapping, fist clenching, and forearm rotation movements to observe brain region activation. | 2 weeks and 4 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine | Shanghai | China | 200092 | China |
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| sham stimulation | Device | The sham group receives 10 sessions of rTMS stimulation with a sham stimulation coil, which emits the same sound and vibration as the active coil but does not produce any induced electrical currents. |
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| ID | Term |
|---|---|
| D018476 | Hypokinesia |
| ID | Term |
|---|---|
| D020820 | Dyskinesias |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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