Clinical Trail of Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Upper Limb Bradykinesia in Parkinson' Disease' Patients

A Randomized Sham-Controlled Trial of High-frequency RTMS in the Treatment of Upper Limb Bradykinesia in Patients with Parkinson's Disease

A randomized, double-blind, sham-controlled unicenter clinical trial was used to investigate the effectiveness and neural mechanism of high-frequency repetitive transcranial magnetic stimulation in the treatment of upper limb bradykinesia in patients with Parkinson's disease.

Inclusion Criteria:

• Hoehn and Yahr (HY) stage 1-2
• Able to understand and cooperate with the study
• Predominantly characterized by bradykinesia
• Onset on the left side

Exclusion Criteria:

• Contraindications for TMS including DBS surgery, Ventriculoperitoneal shunt, etc
• Other neurological disorders
• Significant resting tremor, with MDS-UPDRS-III tremor score ≥3
• Resting threshold cannot be measured
• Received other TMS treatments within the last 3 months