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| Name | Class |
|---|---|
| Chalmers University of Technology | OTHER |
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Low-grade inflammation is involved in the pathogenesis of type 2 diabetes and cardiovascular disease. Increasing evidence suggests that dietary intake may be involved in the inflammatory process. How nutritional composition of the diet affects the inflammatory response is however not well understood.
The aim of this project is to study if intake of three different fat sources induce different effects on inflammation markers, blood lipids, blood glucose and the microbiota.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sequence 1: Rapeseed oil, butter, coconut oil | Experimental | Diets rich in rapeseed oil, butter or coconut oil given in blinded, preprepared meals |
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| Sequence 2: Rapeseed oil, coconut oil, butter | Experimental | Diets rich in rapeseed oil, butter or coconut oil given in blinded, preprepared meals |
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| Sequence 3: Butter, coconut oil , rapeseed oil | Experimental | Diets rich in rapeseed oil, butter or coconut oil given in blinded, preprepared meals |
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| Sequence 4: Butter, rapeseed oil, coconut oil | Experimental | Diets rich in rapeseed oil, butter or coconut oil given in blinded, preprepared meals |
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| Sequence 5: Coconut oil, rapeseed oil, butter | Experimental | Diets rich in rapeseed oil, butter or coconut oil given in blinded, preprepared meals |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Rapeseed oil | Other | During 1 week, 46 % of total energy intake will come from rapeseed oil, using pre-prepared and blinded meals. |
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| Measure | Description | Time Frame |
|---|---|---|
| Total cholesterol | Baseline and 1 week | |
| hs-CRP | High sensitivity C-reactive Protein | Baseline and 1 week |
| Measure | Description | Time Frame |
|---|---|---|
| Inflammation markers | Eg. GlycA, IL6, TNF-a | Baseline and 1 week |
| Blood lipid propfile | Blood lipids and their subfractions, lipoproteins, apolipoproteins |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Gothenburg | Gothenburg | 40530 | Sweden |
It would depend on ethical permission to share the IPD.
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| ID | Term |
|---|---|
| D007249 | Inflammation |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D000074262 | Rapeseed Oil |
| D002079 | Butter |
| D000074263 | Coconut Oil |
| ID | Term |
|---|---|
| D010938 | Plant Oils |
| D009821 | Oils |
| D008055 | Lipids |
| D028321 | Plant Preparations |
| D001688 |
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Meals identical in apperance and taste will be prepared, and blinded.
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| Sequence 6: Coconut oil, butter, rapeseed oil | Experimental | Diets rich in rapeseed oil, butter or coconut oil given in blinded, preprepared meals |
|
| Butter | Other | During 1 week, 46 % of total energy intake will come from butter, using pre-prepared and blinded meals. |
|
| Coconut oil | Other | During 1 week, 46 % of total energy intake will come from coconut oil, using pre-prepared and blinded meals. |
|
| Baseline and 1 week |
| Glucose | Glucose, measured by continuous blood glucose monitoring | Continuous during 1 week |
| Microbiota | Change in gut microbial composition and diversity (alpha- and beta). | Baseline and 1 week |
| Biological Products |
| D045424 | Complex Mixtures |
| D004041 | Dietary Fats |
| D005223 | Fats |
| D003611 | Dairy Products |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |