Lack of funding

The purpose of this study is to compare alveolar ridge augmentation outcomes of two types of membranes for vertical and horizontal mandibular ridge augmentation: Customized CAD/CAM Titanium Mesh versus Reinforced Perforated PTFE Mesh (RPM).

Inclusion Criteria:

• Age ≥ 18 years
• Physical status according to the American Society of Anesthesiology (ASA) I or II, which includes patients who are systematically healthy or may suffer from mild to moderate, however well-controlled systemic diseases.
• Subjects having at least one free end saddle edentulous area of the posterior area of the mandible with moderate horizontal and vertical bone defects >≥3mm.
• Capacity to understand and accept the written conditions of the study.

Exclusion Criteria:

• Insufficient oral hygiene.
• Smoking habit of >10 cigarettes/day (self-reported).
• Abuse of alcohol or drugs.
• Pregnancy or individuals attempting to get pregnant (self-reported).
• Acute local or systemic infections.
• Uncontrolled diabetes or other metabolic disease.
• Severe hepatic or renal dysfunction.
• Autoimmune disorders.
• Patients who underwent radiotherapy in the last 5 years.
• Patients undergoing immunosuppressive therapy or who are immunocompromised.
• Any other contraindications for undergoing surgery.