The investigators propose to expand our previous work to test whether 10 repeated administrations of the cTBS procedure over a two-week period can lead to longer-term improvements in sleep, perhaps up to 3-months. For this 3-year study, 120 people with insomnia will be recruited to participate. There will be an initial screening, with the first consent form being for the screening questions, a psychological interview, and a one night at home sleep monitoring session with our equipment. If participants pass this first phase, they will reconsent for the main portion of the study. They will then undergo a physical examination, then a week-long at-home monitoring phase where they will wear a wristwatch sleep monitor as well as wear a portable brain wave monitor to bed each night to record sleep. Participants will continue to use this equipment throughout the treatment phase and for one week post treatment. After the first monitoring phase, each participant will be randomly assigned to one of four different conditions (i.e., 30 assigned to each group). Three of the conditions will involve cTBS focused on different brain locations (i.e., stimulation to the middle front, middle back, or side of the skull), while the fourth condition will provide inactive sham stimulation as a control. All participants will complete 10 treatment visits to the lab over two-to-three weeks, during which they will get a brief cTBS or sham stimulation each time. In addition, all participants will complete a brain scanning and cognitive testing session at the beginning and end of the two-to-three week treatment period. Participants will also complete 1-month and 3-month online follow-up assessments to examine long-term effects.

Phase 0: Screening and Rule-Outs:

During the REDCap Screening, participants will first read this informed consent form and sign it electronically on REDCap to proceed. To begin the screening questions, they must pass a 10-question comprehension check with questions regarding this document to ensure you understand the study. They will then answer a series of questionnaires related to demographics and health background. The REDCap screener will automatically end the survey if they indicate any exclusion. If you are included in the study, at the end of the screening questions it will indicate so and that we will be in contact with you shortly. They will then undergo a virtual psychological interview to determine if they indeed have Insomnia to qualify for the study. Then, they will be mailed WatchPAT monitoring equipment for them to utilize for one night of sleep monitoring at home. This device will measure their level of Obstructive Sleep Apnea, excluding them if they score >15 AHI. We will review all of this data, and if they are eligible, participants will move on to Phase 1 of the study and undergo a second consent form.

Phase 1 In-Person Screening/Enrollment, Pre-Intervention:

Individuals who are eligible for this study after the three screening points will come into the lab to undergo an informational briefing and physical screening appointment. At this appointment, potential participants will complete the main consent for the rest of the study and get to ask any additional questions they have in person. Then, they will undergo a physical examination with a physician to determine eligibility. During the physical examination, there will be a collection of vital signs, EKG, and urine samples to screen for pregnancy and drugs (Ketamine, cocaine, MDMA, phenylcycline (PCP), and amphetamines). We will not be excluding for marijuana. In addition, individuals will complete evaluations to assess intelligence and cognition. If an individual is physically eligible and wishes to move forward, they will then be sent home and asked to complete 7 days of at-home sleep monitoring. This will include wearing an actigraph and a MUSE headband every night, while completing daily sleep diaries and short surveys every morning.

Phase-2 Baseline/Randomization/Active Intervention:

At the baseline visit participants will be asked to complete several cognitive and emotional assessments, have a pre-TMS neuroimaging scan and Electrocardiogram session, and undergo their first TMS administration. The first TMS administration will follow participant randomization into one of the four study conditions.

Following the baseline visit, during treatment participants will be asked to continue using the MUSE headband and actigraph every night and complete daily sleep diaries every morning. Participants will also be asked to return to the lab for 10 total TMS sessions in 2-3 weeks, all lasting around an hour in the evening. Participants will be administered a PVT task before and after each treatment session.

The kind of TMS we are administering is called Theta Burst Stimulation (TBS). A MagVenture MagPro X100 stimulator (MagVenture Inc. Denmark) connected with a figure-of-eight magnetic coil with active cooling will be used for the TBS protocol. Each individual is expected to have a different sensitivity to the magnetic fields generated by the cTBS, and the stimulation intensity will need to be adjusted based on each individual's resting motor threshold (RMT). Once we determine the RMT, we will set the machine to run at 70% of this level. The stimulation will last 40 seconds.

The ten TMS sessions will last for one hour between 6-9pm on weekdays. Ideally, there would be a session every weekday straight for two full weeks. We understand that this may be difficult for some people. If you need to miss a day or two, that is okay. However, 10 sessions are required. The maximum administration window is 3 weeks. The maximum number of days you can go between TMS sessions is 4 days. Please refrain from engaging in exercise in the time between your evening TMS session and when you go to bed.

Phase 3- Post-Intervention:

After participants complete the two-to-three-weeks of active intervention they will be asked to return to the lab to complete a post-intervention visit. This will involve the same testing as the pre-intervention (baseline) visit (MRI, surveys, and ECG). After this visit, participants will be sent home to continue recording sleep/activity for 7 more nights with the MUSE headband and actigraph, as well as continue recording sleep diaries and short surveys. This is the same as the at-home visit pre-intervention. After post-monitoring, participants will return to the lab for their final close-out visit. During this visit participants will return all study equipment and that will be the last of the in-person visits.

Phase 4- Follow-Up:

Participants who agree during the consent process will be contacted 1-month and 3-months after study completion to complete a series of brief assessments on REDCap, as well as another Psychological Interview at the 1-month follow-up.

Inclusion Criteria:

• Healthy men and non-pregnant women 18-60 (inclusive) years of age free from contraindicated diseases, medications, devices, and conditions.
• Must score in the moderate or higher range on the Insomnia Severity Index (ISI ≥ 15)
• Must meet the criteria for DSM-5 insomnia disorder as determined by a clinical interview with a board-certified sleep medicine physician.
• Sex ratio will be set to ~50% males; ~50% females
• Ethnicity ratio will be set to ~29.5% who identify as a minority; ~70.5% who identify as white

Exclusion Criteria:

• Presence of any metal implant or medical device that may pose a safety risk for MRI or TMS (permanent hearing aids, cochlear implants, medication infusion devices, brain stimulation devices, permanent retainer, etc.)
• Self-reported past or present medical diagnosis of sleep or breathing-related disorders such as sleep apnea other than insomnia (potential confounder);
• Confounder of Obstructive Sleep Apnea as measured by WatchPAT device at home
• Travel outside the time zone within the one week prior to the physical visit and at any point while active in the study (known to affect sleep);
• Regular shiftwork within 6-months prior to enrollment in the study (known to affect sleep);
• Self-reported past or present history of any seizures or seizure disorders or other contraindication to neurostimulation, for self or any first-degree relatives (safety concern);
• Self-reported current use of certain prescription medications that can either influence seizure threshold, or neuroimaging findings (safety concern and potential confounder);
• Self-reported caffeine use in excess of 300 mg (e.g., approximately 8 caffeinated sodas or approximately 3-4 12-oz cups of coffee) per day on average (known to affect sleep; potential confounder);
• Self-reported or suspected substance abuse or dependence (safety concern; potential confounder);
• (Females only) Positive urine pregnancy result (Urine HCG Test results) (safety concern);
• Inability to read and sign the consent form (regulatory/ethical issue)
• Self-reported history of repeated, recent, or severe fainting spell or syncope
• Prior spinal cord surgeries or any spinal/ventricular derivations
• Self-reported negative experience due to neurostimulation before
• Deviation from self-reported normal bedtime sleep schedules (bedtime between 9:00 pm and 1:00 am