Evaluation of a Novel Technique for the Discovery of New, Tumor-specific Targets for the Deployment of Innovative Immunotherapeutics Against Cancer.

Tn-Miner: Technology for the Discovery of Tumor-specific Glycopeptide Immunotherapy Targets.

The goal of this interventional, prospective research on human bodily material is to discover new, cancer-specific molecular structures (i.e. glycopeptides) within surgically removed, estrogen receptor positive breast cancer tumors.

The main goal it aims to achieve is:

To discover tumor-specific targets, that allow the use of very potent immunotherapeutic drugs as treatment for solid tumors, such as estrogen receptor positive breast cancer. These new targets are very specific for cancer cells, meaning that virtually no healthy cells should be attacked by the treatment, resulting in less side effects.

Participants will undergo standard of care treatment, comprising surgical removal of the breast tumor. Part of these tissues will be used for this clinical research.

Inclusion Criteria:

• Female
• Minimally 18 years old
• Diagnosed with estrogen-receptor positive breast cancer
• This must be a primary tumor

Exclusion Criteria:

• Male
• Younger than 18 years old
• Previous history of other tumors