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All participants will clinically evaluated by history taking, full physical examination including body weight and assessment of fluid status, and blood and urine samples for lab analysis (serum creatinine, urea, sodium, potassium, corrected calcium, phosphorous, estimated glomerular filtration rate(GFR) by Cokcroft equation ((140 - age ) x body weight by Kg/creatinine by µmol )complete urine analysis including microscopic examination of urine , 24 hours urinary protein , haemoglobin level .
All participants will undergo renal shear wave elastography measurements. Values will be obtained from the upper, middle, and lower zones of each kidney. A total of six shear wave elastography measurements will be collected to get mean elastography values (MEVs) of each participant.
We will collect results of MEV plus blood and urine samples of each participant then data will undergo statistical analysis to compare between MEV of healthy persons and biopcy proven glomerulonephritis patients
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A: biopcy proven glomerulonephritis patients not started specific treatement | Experimental | agroup of Biopcy proven glomerulonephritis patients not started specific treatement will undergo for renal shear wave elastography |
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| Group B : healthy persons | Experimental | A group of healthy persons will undergo for renal shear wave elastography |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| renal shear wave elastography | Diagnostic Test | Renal shear wave elastography is a non-invasive ultrasound elastography technique that allows measurements of tissue stiffness. It provides real-time measurements of shear wave velocity (SWV) generated with an acoustic impulse, thereby providing quantitative information about tissue elasticity. Harder tissues have been shown to have higher SWV . Renal shear wave elastography will be done to both groups |
| Measure | Description | Time Frame |
|---|---|---|
| comparisons between the shear wave elastography measurements in GN patients and healthy persons . | One year |
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a-inclusion criteria :
adult patients aged 18 years old or more
patients diagnosed as glomerulonephritis ( biopcy proven ) and not started specific tratement in Assiut University Hospitals
b. Exclusion criteria:
patient with urinary tract obstruction
patient who has GN and started corticosteroid and/or immunosuppressive drugs
patient who has congenital anomalies in renal system
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of medicine,Assiut universty,Egypy | Asyut | Asyut Governorate | 2063045 | Egypt |
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