Non-invasive Treatment for Long COVID (Post COVID-19 Condition) Brain Fog

Pilot Study to Investigate Possible Non-invasive Treatment for Long COVID (Post COVID-19 Condition) Brain Fog

This study aims to assess the effects of both acute and chronic exposures to hypoxia and hypercapnia in patients with Long COVID syndrome.

Inclusion criteria:

• English speaking
• Diagnosis of Long COVID

Exclusion criteria:

• Any history of:

  • Coronary artery dissection or aortic dissection
  • Neurological disease (e.g. dementia, Alzheimer's disease, or other brain-related disease)
  • Cerebrovascular disease or stroke
  • Aneurysm

• If currently has:

  • Moderate-severe chronic obstructive pulmonary disease
  • Uncontrolled moderate-severe asthma
  • Moderate-severe bronchiectasis
  • Moderate-severe interstitial lung disease, requiring the use of supplemental oxygen
  • A necessity to use supplemental oxygen, for any reason
  • New or worsening symptoms (decompensation) of heart failure
  • Right heart disease due to chronic pulmonary disease/sleep apnea
  • Uncontrolled myocardial ischemia or angina
  • Uncontrolled heart arrhythmias
  • Heart or lung infection (e.g. myocarditis or pericarditis)
  • Left main coronary artery stenosis
  • Moderate-severe aortic stenosis
  • Pulmonary embolism, pulmonary infarction, or other blood clots
  • Severe respiratory disease
  • Chronic kidney disease
  • Chronic liver disease

• Females of childbearing potential will complete a urine pregnancy test at their baseline visit to rule out pregnancy

• BMI >40

• Study staff unable to obtain adequate signal for cerebral blood flow