Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Introduction: Several studies have evaluated and confirmed the ergogenic effect of acute caffeine intake on sports performance, specifically on strength and power performance. However, it remains to be elucidated how CYP1A2 polymorphism influences the prolonged effects of caffeine on this type of exercise.
Objectives: The present study aims to analyze the prolonged effects of caffeine intake on neuromuscular adaptations to resistance training according to CYP1A2 polymorphism in men and women.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Genotype AA - Male - Caffeine | Experimental |
| |
| Genotype AC or CC - Male - Caffeine | Experimental |
| |
| Genotype AA - Male - Placebo | Placebo Comparator |
| |
| Genotype AC or CC - Male - Placebo | Placebo Comparator |
| |
| Genotype AA - Female - Caffeine | Experimental |
| |
| Genotype AC or CC - Female - Caffeine | Experimental |
| |
| Genotype AA - Female - Placebo | Placebo Comparator |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Caffeine and Resistance training | Dietary Supplement | Acute caffeine intake (3 mg/kg) prior each resistance training session of a 8 weeks training program. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Mean velocity at different %1RM | Measuring bar mean velocity desplacement during bench press and back squat exercises. | Through study completion, an average of 12 weeks |
| Peak velocity at different %1RM | Measuring bar peak velocity and time to reach peak velocity of bar desplacement during bench press and back squat exercises. | Through study completion, an average of 12 weeks |
| Mean power output at different %1RM | Measuring during bench press and back squat exercises. | Through study completion, an average of 12 weeks |
| Peak power output and time to reach peak power output at different %1RM | Measuring during bench press and back squat exercises. | Through study completion, an average of 12 weeks |
| Number of repetitions performed at 65%1RM until task failure | In bench press and back squat exercises | Through study completion, an average of 12 weeks |
| Bar velocity deplacement performed in 1 set at 65%1RM until task failure | In bench press and back squat exercises | Through study completion, an average of 12 weeks |
| Power output generated in 1 set at 65%1RM until task failure | In bench press and back squat exercise | Through study completion, an average of 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Fat-free mass | Using electrical bioimpedance and untrasound in the quadriceps muscle | Through study completion, an average of 4 weeks |
| Fat mass | Using electrical bioimpedance (kg and % of body mass) |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Facultad de Medicina y Ciencias de la Salud. Universidad de Alcalá | Alcalá de Henares | Madrid | 28805 | Spain |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D002110 | Caffeine |
| D055070 | Resistance Training |
| ID | Term |
|---|---|
| D014970 | Xanthines |
| D000470 | Alkaloids |
| D006571 | Heterocyclic Compounds |
| D011688 | Purinones |
Not provided
Not provided
Not provided
Not provided
Not provided
Statistician
|
| Genotype AC or CC - Female - Placebo | Placebo Comparator |
|
| Placebo and Resistance training | Dietary Supplement | Acute placebo intake (3 mg/kg of maltodextrin) prior each resistance training session of a 8 weeks training program. |
|
| Resting Metabolic Rate (RMR) | Kcal at rest using a metabolic chart. | Through study completion, an average of 12 weeks |
| Maximal Fat Oxidation Rate (MFO) | g/min (MFO) using a metabolic chart. | Through study completion, an average of 12 weeks |
| Through study completion, an average of 12 weeks |
| Physical activity (METs-min/wk) | Using IPAQ | Through study completion, an average of 12 weeks |
| Dietary (g/kg of macronutrients) | Using a 24-total recall | Through study completion, an average of 12 weeks |
| Mood state | Participants graded a set of 29 items related to the mood on a Likert scale from 0 (not at all) to 4 (extremely) in reply to the question;How do you feel at this moment?; to assess six scales: tension, depression, anger, vigor, fatigue and confusion. | Through study completion, an average of 12 weeks |
| Adverse effects | Adverse effects. perception of power, endurance, energy and exertion, as well as heart, muscular and gastrointestinal discomfort. | Through study completion, an average of 12 weeks |
| D011687 |
| Purines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D005081 | Exercise Therapy |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
| D005791 | Patient Care |
| D013812 | Therapeutics |
| D026741 | Physical Therapy Modalities |
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |