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| Name | Class |
|---|---|
| Agri-Food and Biosciences Institute | OTHER |
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This study will investigate the impact of consuming grass-finished lamb meat on blood omega-3 PUFAs and cardiovascular risk factors compared to concentrate-finished lamb meat. Healthy volunteers will consume three portions of lamb meat/week from a grass-finished meat treatment or a concentrate-finished meat treatment for four weeks. Blood samples will be taken at weeks zero and four. The primary outcome is to assess difference in change in omega-3 PUFA concentration in plasma and platelets between treatment groups. The secondary outcome is to assess between groups differences in change in cardiovascular disease risk factors including blood pressure, BMI and lipids among healthy individuals.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Concentrate/ Cereal fed lamb | No Intervention | Participants to consume three portions of lamb per week for four consecutive weeks. The lamb diet was a concentrate/cereal pellet. | |
| Grass fed lamb | Experimental | Participants to consume three portions of lamb per week for four consecutive weeks. The lamb diet was grass only. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Grass fed lamb | Other | This study investigated the impact of consuming grass finished lamb on total blood plasma and blood plasma phospholipids (PL) FA and on cardiovascular risk factors, including heart rate, blood pressure (BP), HDL-cholesterol, LDL-cholesterol, and TAG cholesterol, in humans. |
| Measure | Description | Time Frame |
|---|---|---|
| Fatty acid (%) change in blood plasma between treatments | Primary outcome is to assess the impact of consuming grass vs concentrate finished lamb on blood plasma response in healthy volunteers | Week 0 and week 4 |
| Fatty acid change (%) in blood plasma phospholipids between treatments | Primary outcome is to assess the impact of consuming grass vs concentrate finished lamb on blood plasma phospholipid response in healthy volunteers | Week 0 and week 4 |
| Measure | Description | Time Frame |
|---|---|---|
| Change in weight (kg) in participants between treatments | Secondary outcome is to assess the impact of consuming grass vs concentrate finished lamb on weight among healthy volunteers | Week 0 and week 4 |
| Change in Body Mass Index (BMI) in participants between treatments - calculated by dividing weight (kg) by height in meters squared |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Nigel D Scollan, PhD | Queen's University, Belfast | Principal Investigator |
| Jayne V Woodside, PhD | Queen's University, Belfast | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| School of Biological Sciences, Queen's University Belfast | Belfast | BT9 5DL | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40690019 | Derived | Perkins LS, Nugent AP, Woodside JV, Cardwell CR, Scollan ND. Consuming grass finished lamb improves blood plasma omega-3 fatty acid response among healthy consumers. Eur J Nutr. 2025 Jul 21;64(5):242. doi: 10.1007/s00394-025-03765-z. |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Mar 22, 2019 | Jul 31, 2024 | Prot_SAP_000.pdf |
| ICF | No | No | Yes | Informed Consent Form | Mar 22, 2019 | Jul 31, 2024 | ICF_001.pdf |
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Describe parallel arms
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Describe it was the participant
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Secondary outcome is to assess the impact of consuming grass vs concentrate finished lamb on weight and BMI response in healthy volunteers |
| Week 0 and week 4 |
| Cholesterol | Secondary outcome is to assess the impact of consuming grass vs concentrate finished lamb on total cholesterol, LDL, HDL and TAG response in healthy volunteers | Week 0 and week 4 |
| Blood pressure (diastolic and systolic) | Secondary outcome is to assess the impact of consuming grass vs concentrate finished lamb on blood pressure (diastolic and systolic) response in healthy volunteers | Week 0 and week 4 |