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Analysis of the effect of dietary intervention based on increased polyunsaturated fatty acid intake on health. Specifically changes in blood lipid profile, as well as proteomic and metabolomic profiles of healthy adults will be analyzed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| The high PUFA diet group | Experimental | This will receive detailed nutritional recommendations and will consume at least 4 table spoons of olive oil or 30 grams of nuts daily for 12 weeks. |
|
| Control group | No Intervention | The Control group will receive general nutritional recommendations based on Human Nutrition Recommendations for Polish Population. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| The high PUFA diet group | Other | Assumptions of nutritional intervention: in a randomized manner volunteers will be assigned to one of two groups: a control group which will receive general nutritional recommendations, based on the Polish nutrition pyramid, and the intervention group which will receive nutritional recommendations, based on the Polish nutrition pyramid and will consume at least 4 tablespoons of olive oil or 30 grams of nuts every day for 12 weeks. |
| Measure | Description | Time Frame |
|---|---|---|
| Nutrient intake | Nutrient intake (3-day food records) | 12 weeks |
| Concentrations of lipoproteins and glucose | Serum concentrations of lipoproteins and glucose at baseline and after the intervention [mg/dl] | 12 weeks |
| Proteomic analysis of plasma | The aim is to identify biomarkers in the blood and to determine the differences between people from the control and the intervention group | 12 weeks |
| Metabolite concentrations in plasma | Metabolite concentrations in plasma samples are measured by high resolution mass spectrometry at baseline and after the intervention | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Body mass | body mass at baseline and after the intervention | 12 weeks |
| Height | height | 12 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Joanna Ciborska, Ph.D | Contact | +48 664 985 896 | joanna.ciborska@uwm.edu.pl | |
| Agata Chmurzynska, Ph.D | Contact | + 48 61 846 61 81 | agata.chmurzynska@up.poznan.pl |
| Name | Affiliation | Role |
|---|---|---|
| Agata Chmurzynska, PhD | Poznan University of Life Sciences | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Poznan University of Life Sciences | Recruiting | Poznan | Poland |
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| Percentage body fat | percentage body fat at baseline and after the intervention | 12 weeks |
| Waist circumference | waist circumference at baseline and after the intervention | 12 weeks |
| hip circumference | hip circumference at baseline and after the intervention | 12 weeks |