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The goal of this clinical trial is to evaluate the relationship between obesity and gingival crevicular fluid resistin and adiponectin in periodontitis patients as well as assess the effect of non-surgical periodontal therapy on their levels using ELISA in obese individuals. Researchers will compare different stages of periodontitis to see if degrees of inflammation and periodontal therapy related obesity
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| mild periodontitis (first stage, grade B) | Active Comparator | mild periodontitis (first stage, grade B) manifesting CAL ≥ 1-2 mm, in corporation with percentage of bone loss level divided by age was 0.25-1% very year. patients received non-surgical full-mouth periodontal therapy without using adjunct disinfectants. |
|
| moderate periodontitis (second stage, grade B) | Active Comparator | moderate periodontitis (second stage, grade B) manifesting CAL ≥ 3-4mm in corporation with percentage of bone loss level divided by age was 0.25-1% very year. patients received non-surgical full-mouth periodontal therapy without using adjunct disinfectants. |
|
| severe periodontitis (third stage, grade B) | Active Comparator | severe periodontitis (third stage, grade B) manifesting CAL ≥ 5mm , in corporation with BoP increased than (30%), percentage of bone loss level divided by age was 0.25-1% very year. patients received non-surgical full-mouth periodontal therapy without using adjunct disinfectants |
|
| very severe periodontitis (forth stage, grade C) | Active Comparator |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| non-surgical full-mouth periodontal therapy without using adjunct disinfectants | Procedure | Supragingival scaling was performed by Ultrasonic Scaler and manual scaling by sickle scaler . Subgingival scaling and root planing were accomplished with either universal or area specific Gracey curettes |
| Measure | Description | Time Frame |
|---|---|---|
| adiponectin level in gingival crevicular fluid | From enrollment to the end of treatment results assessment at 12 weeks | |
| resistin level in gingival crevicular fluid | From enrollment to the end of treatment results assessment at 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| O'Leary Plaque score | From enrollment to the end of treatment results assessment at 12 weeks | |
| bleeding on probing percentage (BoP) | From enrollment to the end of treatment results assessment at 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Body Mass Index (BMI) | From enrollment time only | |
| glycated hemoglobin (HbA1c) | From enrollment time only |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Bahaa Mohammed Badr, associate professor | Faculty of dental medicine Al-Azhar university Assiut Branch | Study Director |
| Asem Mohammed kamel, lecturer | Faculty of dental medicine Al-Azhar university Assiut Branch | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Dental Medicine, Al-Azhar University Assiut Branch | Asyut | Asyut Governorate | 71524 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 16104844 | Background | Kusminski CM, McTernan PG, Kumar S. Role of resistin in obesity, insulin resistance and Type II diabetes. Clin Sci (Lond). 2005 Sep;109(3):243-56. doi: 10.1042/CS20050078. | |
| 19740705 | Background | Filkova M, Haluzik M, Gay S, Senolt L. The role of resistin as a regulator of inflammation: Implications for various human pathologies. Clin Immunol. 2009 Nov;133(2):157-70. doi: 10.1016/j.clim.2009.07.013. Epub 2009 Sep 8. |
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very severe periodontitis (forth stage, grade C) manifesting CAL ≥ 5mm in corporation of percentage of bone loss level divided by age more than 1% very year. patients received non-surgical full-mouth periodontal therapy without using adjunct disinfectants
|
|
| GCF level of adiponectin and resistin | Diagnostic Test | Gingival crevicular fluid (GCF) samples were gathered and relocated in phosphate buffer saline inside Eppendorf tube then t they were manipulated by commercially available enzyme-linked immuno-sorbent assay |
|
| clinical attachment level (CAL) | From enrollment to the end of treatment results assessment at 12 weeks |
| probing pocket depth | From enrollment to the end of treatment results assessment at 12 weeks |
| 10674959 | Background | Cugini MA, Haffajee AD, Smith C, Kent RL Jr, Socransky SS. The effect of scaling and root planing on the clinical and microbiological parameters of periodontal diseases: 12-month results. J Clin Periodontol. 2000 Jan;27(1):30-6. doi: 10.1034/j.1600-051x.2000.027001030.x. |
| ID | Term |
|---|---|
| D010510 | Periodontal Diseases |
| D009767 | Obesity, Morbid |
| ID | Term |
|---|---|
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D009765 | Obesity |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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