The REgistry of Very Early Estrogen and AnovuLation

The REgistry of Very Early Estrogen and AnovuLation

The purpose of this study is to to build a registry of women with early estrogen loss due to Functional Hypothalamic Amenorrhea (FHA) to understand the prevalence, racial and ethnic diversity of this condition.

Inclusion Criteria:

• 3 or more months of consecutive amenorrhea with a diagnosis of functional hypothalamic amenorrhea or screening hormones consistent with functional hypothalamic amenorrhea including but not limited to:

  • Estradiol: < 50pg/mL
  • LH: < 10 IU/mL
  • FSH: < 10 IU
  • Testosterone: 2 - 45 ng/dL
  • Free Testosterone: 0.1 - 6.4 pg/mL
  • FT4: 0.93 - 1.70 ng/dL
  • Prolactin: < 20 ng/mL
  • AMH: > 1 ng/mL
  • Urine or serum human chorionic gonadotropin: Negative

• LH:FSH Ratio <1

• No signs of male-like hair growth on the upper lip, chin, chest, abdomen, buttocks, or back

• Does not have a diagnosis for secondary amenorrhea, including prolactinoma, PCOS, premature ovarian insufficiency, pituitary surgery, infection, or infarction

• Premenopausal status determined by WISE criteria

• Able to give informed consent

• Able to read English

Exclusion Criteria:

• Parturition/lactating in the last 6-12 months
• Lack of consent