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The study aims to assess the anti-aging and photoprotective efficacy of two active concentrations of a food supplement composed of Coriander Seed Oil (CSO).
A double blind, parallel groups, placebo-controlled study is carried out on 90 female subjects aged between 35 and 65 years old with visible Crow's feet wrinkles and mild to moderate skin slackness.
The study foresees 56 days of products intake. Evaluations of the parameters under study are performed at baseline, after 14, 28 and 56 days of products consumption.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Coriander Seed Oil - Dose 1 | Experimental | Dietary supplement - Coriander Seed Oil dose 1 |
|
| Coriander Seed Oil - Dose 2 | Experimental | Dietary supplement - Coriander Seed Oil dose 2 |
|
| Placebo | Placebo Comparator | Dietary supplement - Placebo |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Coriander Seed Oil - Dose 1 | Dietary Supplement | The study foresees the intake of 1 capsule per day during 56 days |
|
| Measure | Description | Time Frame |
|---|---|---|
| Skin profilometry | Primos 3D | Baseline |
| Skin profilometry | Primos 3D | 14 days |
| Skin profilometry | Primos 3D | 28 days |
| Skin profilometry | Primos 3D | 56 days |
| Measure | Description | Time Frame |
|---|---|---|
| Skin elasticity | Cutometer | Baseline |
| Skin elasticity | Cutometer | 14 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Eleonora Spartà | Complife Italia Srl | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Complife Italia S.r.l | San Martino Siccomario | 27028 | Italy |
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| Coriander Seed Oil - Dose 2 | Dietary Supplement | The study foresees the intake of 1 capsule per day during 56 days |
|
| Placebo | Dietary Supplement | The study foresees the intake of 1 capsule per day during 56 days |
|
| Skin elasticity |
Cutometer |
| 28 days |
| Skin elasticity | Cutometer | 56 days |
| Transepidermal water loss | Tewameter | Baseline |
| Transepidermal water loss | Tewameter | 14 days |
| Transepidermal water loss | Tewameter | 28 days |
| Transepidermal water loss | Tewameter | 56 days |
| Erythema index | Skin haemoglobin quantification by Mexameter 24h after UV exposure | Baseline |
| Erythema index | Skin haemoglobin quantification by Mexameter 24h after UV exposure | 28 days |
| Erythema index | Skin haemoglobin quantification by Mexameter 24h after UV exposure | 56 days |
| Skin inflammation (subgroup of 20 subjects) | TNF-alpha quantification by Enzyme-Linked Immunosorbent Assay on skin stripping performed before and 24h after UV exposure | Baseline |
| Skin inflammation (subgroup of 20 subjects) | TNF-alpha quantification by Enzyme-Linked Immunosorbent Assay on skin stripping performed before and 24h after UV exposure | 56 days |
| Skin lipoxidation (subgroup of 20 subjects) | Malondialdehyde quantification by spectrophotometry on skin stripping performed before and 4h and 24h after UV exposure | Baseline |
| Skin lipoxidation (subgroup of 20 subjects) | Malondialdehyde quantification by spectrophotometry on skin stripping performed before and 4h and 24h after UV exposure | 56 days |
| Self-assessment of product efficacy | Questionnaire (10 questions with 4 possible answers : completely agree / agree / disagree / completely disagree) | 56 days |