Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The purpose of this study is to investigate areas of the brain responsible for avoidance learning in adults with eating disorders using brain imaging techniques, computer tasks, and self-report questionnaires and interviews. The investigators will study changes in brain activity using a procedure called functional magnetic resonance imaging (fMRI). This study will include 78 women with an eating disorder (26 with anorexia nervosa [AN], 26 with bulimia nervosa [BN]) and 26 healthy controls (HC) aged 18-39.
Aim 1: Evaluate behavioral differences in active and passive avoidance learning in eating disorders and associations with symptoms.
Aim 2: Evaluate whether corticostriatal and limbic-prefrontal fMRI BOLD response associated with avoidance learning differs in eating disorders relative to healthy controls and relates to symptoms.
Aim 3: Evaluate whether functional connectivity of avoidance learning neural circuity differs in eating disorders relative to healthy controls.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Anorexia Nervosa | Participants that meet Diagnostic And Statistical Manual Of Mental Disorders (DSM-V) criteria for Anorexia Nervosa. | ||
| Bulimia Nervosa | Participants that meet DSM-V criteria for Bulimia Nervosa. | ||
| Healthy Controls | Participants that do not meet DSM-V criteria for any disorder. |
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Learning rate | Behavioral responses during a card game gambling task | 25 minutes |
| fMRI brain response | fMRI brain activity associated with the card game gambling task | 25 minutes |
| Brain connectivity | Whole-brain functional connectivity associated with the card game gambling task | 10 minutes |
Not provided
Not provided
Inclusion Criteria:
Eating Disorder Group:
Healthy Controls:
Exclusion Criteria:
Additional Exclusion Criteria for ED Group:
Additional Exclusion Criteria for Healthy Control Group:
Not provided
Not provided
The study will recruit 52 adult women currently ill with an eating disorder, including anorexia nervosa (AN; n=26) and bulimia nervosa (BN, n=26), and 26 healthy control (HC) women between the ages of 18 and 39.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Christina E Wierenga, PhD | Contact | 858-534-8047 | cwierenga@health.ucsd.edu |
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UCSD Eating Disorders Treatment and Research Program | Recruiting | La Jolla | California | 92121 | United States |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D052018 | Bulimia Nervosa |
| D000856 | Anorexia Nervosa |
| ID | Term |
|---|---|
| D001068 | Feeding and Eating Disorders |
| D001523 | Mental Disorders |
Not provided
Not provided
Not provided
Not provided
Not provided