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The purpose of this study is to investigate areas of the brain responsible for 'liking', 'wanting', and learning in adults with eating disorders using brain imaging techniques, computer tasks, a test meal, and self-report questionnaires and interviews. The investigators will study changes in brain activity using a procedure called functional magnetic resonance imaging (fMRI). This study will include 252 women with an eating disorder (63 AN-restricting type (AN-R), 63 AN-binge eating/purging type (AN-BP), 63 bulimia nervosa (BN)) and 63 healthy controls (HC) aged 18-39.
Aim 1: To examine neural differences in 'liking' and 'wanting' in ED relative to HC.
Aim 2: To examine differences in instrumental learning for reward and punishment in ED relative to HC.
Aim 3: To examine how 'liking' and 'wanting' drive instrumental learning in ED and predict clinical symptoms at baseline and 1 year later.
Exploratory Aim: To explore the associations of dopamine function, as measured by neuromelanin MRI (NM-MRI), with ED diagnosis and brain response to 'liking', 'wanting', and learning.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| AN-R | Participants that meet Diagnostic And Statistical Manual Of Mental Disorders (DSM-V) criteria for Anorexia Nervosa restricting subtype. | ||
| AN-BP | Participants that meet DSM-V criteria for Anorexia Nervosa binging/purging subtype | ||
| BN | Participants that meet DSM-V criteria for Bulimia Nervosa. | ||
| Healthy Controls | Participants that do not meet DSM-V criteria for any disorder. |
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| Measure | Description | Time Frame |
|---|---|---|
| BOLD response | Brain activity associated with 'liking', 'wanting', and learning | 1 Year |
| Reward and Punishment Learning | Task reinforcement learning rate in reward and punishment trials | 1 Year |
| Connectome-based predictive modeling (CPM) | Functional connectivity maps from task-based fMRI data and clinical data | 1 Year |
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Inclusion Criteria:
Eating Disorder Group:
Healthy Control Group:
Exclusion Criteria:
All Groups:
Additional Exclusion Criteria for ED Group:
-If taking other psychotropic medication, any change in dosage in the 2 weeks before scanning
Additional Exclusion Criteria for Healthy Control Group:
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The study will recruit 189 adult women currently ill with ED including anorexia nervosa, restricting type (AN-R, n=63), AN binge eating/purging type (AN-BP, n=63), and bulimia nervosa (BN, n=63) and 63 healthy control (HC) women between the ages of 18 and 39.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Christina Wierenga | Contact | 858-534-8047 | cwierenga@health.ucsd.edu |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UCSD Eating Disorders Treatment and Research Program | Recruiting | La Jolla | California | 92121 | United States |
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| ID | Term |
|---|---|
| D000856 | Anorexia Nervosa |
| D052018 | Bulimia Nervosa |
| ID | Term |
|---|---|
| D001068 | Feeding and Eating Disorders |
| D001523 | Mental Disorders |
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