Background: Osteoarthritis (OA) is a prevalent form of arthritis worldwide. Intra-articular stromal vascular fraction (SVF) injections are a potential therapeutic option for patients with OA. This study aims to assess the effects of intra-articular SVF injections on knee OA. Methods: Ten patients with knee OA participated in this study. After being administered intra-articular SVF injections, their outcomes were evaluated using various questionnaires. MRI T2 mapping was conducted and compared before the intervention and 6 months after. All data underwent analysis using various tests.

Inclusion Criteria:

• Aged ≥ 35 years.
• Patients with degenerative knee OA confirmed via X-ray and classified according to the Kellgren Lawrence Grading Scale 2~4.
• Persistent knee pain after nonsurgical treatment.

Exclusion Criteria:

• Arthritis caused by other systemic or local immune diseases.
• Patients who have undergone total knee replacement surgery.
• Patients who have been administered platelet-rich plasma or hyaluronic acid injections within the past three months.
• Patients with symptoms related to degenerative arthritis in the ankle, which affected the assessment of pain.
• Patients with severe heart problems and coagulation disorders.
• Patients who have taken glucosamine within the previous month.
• MRI exclusion conditions, including patients with a heart rhythm regulator who have received vascular surgery with a hemostatic clip and artificial heart valves.